Cerebellar and oculomotor dysfunction induced by rapid infusion of pethidine.

Author: ChuPo-Wei, DaiYang-Hong, OuKuang-Ling

Paper Details 
Original Abstract of the Article :
Pethidine is an opioid that gains its popularity for the effective pain control through acting on the opioid-receptors. However, rapid pain relief sometimes brings about unfavourable side effects that largely limit its clinical utility. Common side effects include nausea, vomiting and hypotension. I...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962981/

データ提供:米国国立医学図書館(NLM)

Pethidine's Inhibitory Effects on Cerebellar and Oculomotor Function

Pethidine, a commonly used opioid, is like a double-edged sword in the desert of pain management. It effectively relieves pain but can also cause unwanted side effects. This case report investigates the inhibitory impacts of pethidine on the central nervous system (CNS), particularly on the cerebellum and oculomotor function.

The report highlights the potential for rapid pethidine infusion to induce cerebellar and oculomotor dysfunction, characterized by dysmetria, dysarthria, reduced smooth pursuit gain, and decreased saccadic velocity. These effects are like a sandstorm disrupting the delicate balance of a desert ecosystem.

Understanding the Side Effects of Pethidine

This case report sheds light on a less commonly discussed side effect of pethidine. It's like discovering a hidden canyon in the vast desert, revealing a new aspect of the landscape. This study underscores the importance of understanding the potential complications associated with pethidine, especially in patients with impaired renal or liver function or those requiring long-term pain management.

Cautious Approach to Pethidine Use

This report emphasizes the need for careful consideration when administering pethidine, especially in patients with pre-existing conditions. Just like navigating a desert, it's essential to be aware of potential pitfalls and adjust your path accordingly. Clinicians must weigh the benefits of pethidine against the potential risks, particularly for those with compromised renal or liver function.

Dr.Camel's Conclusion

This case report highlights the potential for pethidine to induce cerebellar and oculomotor dysfunction, highlighting the importance of understanding the full range of its effects. Like a wise camel navigating the desert, clinicians must be aware of the potential complexities of this widely used opioid.

Date :
  1. Date Completed 2014-10-22
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24618873

DOI: Digital Object Identifier

PMC3962981

Related Literature

SNS
PICO Info
in preparation
Languages

English

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