Cytotoxic effects of betaxolol on healthy corneal endothelial cells both in vitro and in vivo.

Author: FanTing-Jun, GeYuan, MiaoYing, QiuYue, SunQian, WenQian, YuMiao-Miao

Paper Details 
Original Abstract of the Article :
AIM: To demonstrate the cytotoxic effect of betaxolol and its underlying mechanism on human corneal endothelial cells (HCE cells) in vitro and cat corneal endothelial cells (CCE cells) in vivo, providing experimental basis for safety anti-glaucoma drug usage in clinic of ophthalmology. METHODS: In ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949452/

データ提供:米国国立医学図書館(NLM)

Betaxolol: A Potential Threat to Corneal Endothelial Cells

The eye, like a precious desert oasis, is susceptible to various threats. This research investigates the cytotoxic effects of betaxolol, a commonly used anti-glaucoma drug, on corneal endothelial cells. The study reveals that betaxolol can induce apoptosis in both human and cat corneal endothelial cells, both in vitro and in vivo. The findings raise concerns about the potential for betaxolol to damage corneal endothelium, potentially impacting vision.

A Potential Risk to Vision

This study highlights the potential for betaxolol to induce apoptosis in corneal endothelial cells, potentially leading to vision impairment. The findings suggest that careful monitoring and consideration of alternative treatments may be warranted for patients who are at risk for corneal endothelial damage.

Health Implications and Lifestyle Applications

Individuals using betaxolol for glaucoma treatment should discuss any concerns about potential side effects with their healthcare providers. Regular eye exams and monitoring of corneal endothelial health are essential for detecting any early signs of damage.

Dr.Camel's Conclusion

This study underscores the importance of balancing the therapeutic benefits of glaucoma medications with potential risks to corneal health. Further research is needed to fully understand the long-term effects of betaxolol on corneal endothelium and develop safer alternatives if necessary.

Date :
  1. Date Completed 2014-03-17
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24634857

DOI: Digital Object Identifier

PMC3949452

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