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Pharmacokinetics of two low-dose levonorgestrel-releasing intrauterine systems and effects on ovulation rate and cervical function: pooled analyses of phase II and III studies.

Author: ApterDan, Gemzell-DanielssonKristina, HauckBrian, RosenKimberly, ZurthChristian

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pooled pharmacokinetic and pharmacodynamic analyses of phase II and III studies comparing levonorgestrel intrauterine system (LNG-IUS) 13.5 mg and LNG-IUS 19.5 mg to LNG-IUS 20 μg/24 h found that LNG-IUS 13.5 mg and LNG-IUS 19.5 mg resulted in lower systemic exposure to LNG, lower incidence of anovulation, and similar progestin impact on the endometrium and cervical function.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To assess the pharmacokinetics and pharmacodynamics of levonorgestrel intrauterine system (LNG-IUS) 13.5 mg and LNG-IUS 19.5 mg (total content). DESIGN: Pooled pharmacokinetic and pharmacodynamic analyses of phase II and III studies. SETTING: Randomized, open-label, multicenter studies....See full text at original site
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引用元：
https://doi.org/10.1016/j.fertnstert.2014.03.004

データ提供：米国国立医学図書館（NLM）

Low-Dose Levonorgestrel Intrauterine Systems: Pharmacokinetics and Effects

Ever wondered how things work behind the scenes? This study takes us on a fascinating journey into the world of levonorgestrel intrauterine systems (LNG-IUS), those tiny but mighty devices used for contraception. It examines the pharmacokinetics (how the body processes a drug) and pharmacodynamics (how the drug affects the body) of two different low-dose LNG-IUS devices.

Think of it like a camel carrying a load of precious spices across the desert. The study compares the amount of levonorgestrel released and its impact on ovulation rates and cervical function. The researchers found that both low-dose devices released less levonorgestrel, resulting in fewer anovulatory cycles, while still effectively impacting cervical function.

Low-Dose LNG-IUS: A Balancing Act

The study found that low-dose LNG-IUS devices release lower amounts of levonorgestrel, leading to a lower incidence of anovulation while maintaining similar progestin effects on the cervix and endometrium. This suggests a more balanced approach to contraception, offering a potential advantage for women seeking to minimize potential side effects.

Contraception and Your Health

Choosing the right contraceptive method is essential for your health and well-being. If you're considering an LNG-IUS, talk to your doctor about the different options available and their potential effects. They can help you find the best fit for your needs, ensuring a smooth journey on your family planning path.

Dr. Camel's Conclusion

This study offers valuable information for women considering low-dose LNG-IUS devices. Like a well-stocked camel with a comfortable pack, these devices can provide effective contraception while minimizing potential side effects. Remember, consult your doctor to find the best option for your individual needs!

Date :
  1. Date Completed 2014-07-18
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24726226

DOI: Digital Object Identifier

10.1016/j.fertnstert.2014.03.004

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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