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Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans.

Author: FujitaTomoe, HoritaShigeru, IkedaYasuhiko, KondoTsunenori, KumagaiYuji, KusuharaHiroyuki, MaedaKazuya, NakayamaHideki, SugiyamaYuichi, TanabeKazunari, TianYing

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Adefovir and benzylpenicillin are selective probe substrates for OAT1 and OAT3, respectively. A clinical study showed that probenecid and PAH inhibited the renal clearance of adefovir, while probenecid reduced the clearance of benzylpenicillin, and PAH unexpectedly increased it. These findings suggest that adefovir and benzylpenicillin can be used as probe drugs for OAT1 and OAT3, and PAH can be used to investigate the role of OAT1 in drug excretion.
Paper Details　
Original Abstract of the Article :
Probe substrates for, and inhibitors of, specific transporters are desired to evaluate quantitatively the in vivo functions of transporters in humans. Based on published data, adefovir and benzylpenicillin were selected as organic anion transporter (OAT) 1- and OAT3-selective probe substrates, respe...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejps.2014.04.004

データ提供：米国国立医学図書館（NLM）

Unveiling the Mysteries of Renal Transport: A Study of OAT1 and OAT3

This research delves into the complex world of renal transport, investigating the roles of two key transporters, OAT1 and OAT3, in the elimination of drugs from the body. It's like exploring a desert oasis, seeking to understand the intricate mechanisms that govern the flow of water and nutrients through this vital ecosystem. Researchers investigated the effects of two drugs, p-aminohippurate and probenecid, on the renal clearance of two probe drugs, adefovir and benzylpenicillin, known to be transported by OAT1 and OAT3, respectively. The study provides valuable insights into the interactions between different drugs and these transporters, revealing the intricate dance of drug elimination in the kidney.

Understanding the Intricacies of Drug Elimination

This study illuminates the complex world of drug elimination in the kidney, highlighting the importance of understanding the roles of key transporters like OAT1 and OAT3. It emphasizes the need for careful consideration of potential drug interactions that can affect the elimination of medications from the body. It's like navigating a desert with hidden currents, understanding the flow of water and nutrients is crucial for survival.

A Deeper Understanding of Drug Interactions

This research provides a deeper understanding of drug interactions, offering valuable insights into the mechanisms that govern drug elimination. It underscores the importance of careful medication selection and monitoring to minimize potential side effects and ensure effective treatment. It's like having a detailed map of the desert, allowing us to navigate the intricate network of drug interactions with greater precision.

Dr.Camel's Conclusion

This study sheds light on the intricate world of renal transport, highlighting the important roles of OAT1 and OAT3 in drug elimination. It underscores the importance of understanding potential drug interactions and the need for careful medication selection and monitoring to ensure optimal treatment outcomes. It's like exploring a vast and intricate desert landscape, where understanding the mechanisms of water flow and nutrient transport is crucial for navigating this challenging terrain.
Date :
  1. Date Completed 2015-01-15
  2. Date Revised 2014-06-02
Further Info :

Pubmed ID

24747579

DOI: Digital Object Identifier

10.1016/j.ejps.2014.04.004

Related Literature

Article Analysis
・Effects of adefovir・Effects of probenecid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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