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Management of chronic hepatitis B in children: an unresolved issue.

Author: CainelliFrancesca, ComparcolaDonatella, Della CorteClaudia, NobiliValerio, VentoSandro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

While chronic hepatitis B virus (HBV) infection in childhood typically has a benign course, a small percentage develop cirrhosis or hepatocellular carcinoma. This review discusses the natural history and treatment of chronic HBV in children, focusing on key aspects and unanswered questions regarding management.
Paper Details　
Original Abstract of the Article :
Although a rather benign course of chronic hepatitis B virus (HBV) infection during childhood has been described, 3-5% and 0.01-0.03% of chronic carriers develop cirrhosis or hepatocellular carcinoma before adulthood. Considering the whole lifetime, the risk of hepatocellular carcinoma rises to 9-24...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/jgh.12550

データ提供：米国国立医学図書館（NLM）

Chronic Hepatitis B in Children: A Complex and Challenging Journey

Chronic hepatitis B virus (HBV) infection can have a significant impact on children's health, potentially leading to cirrhosis and hepatocellular carcinoma. This review examines the current knowledge regarding the natural history and treatment of chronic hepatitis B in children. The authors highlight the limitations of current therapeutic options, including the risk of viral resistance, and discuss the challenges in managing childhood HBV infection.

Navigating the Desert of HBV Treatment: Seeking Optimal Strategies

This review highlights the complexities of managing chronic HBV infection in children. It's like navigating a vast desert, where the path to effective treatment is often uncertain. The authors emphasize the need for personalized treatment approaches based on factors such as the stage of disease and the individual patient's characteristics. Continued research is crucial for developing more effective and safe treatments, especially for children who are particularly vulnerable to the long-term consequences of HBV infection.

A Journey Towards a Healthier Future: Investing in Research and Prevention

This review emphasizes the importance of ongoing research and prevention efforts to combat chronic HBV infection. It's a journey towards a healthier future, a path that requires investment in research, public health initiatives, and widespread vaccination programs. By working together, we can build a brighter future for children, protecting them from the devastating effects of HBV infection.

Dr. Camel's Conclusion

This review provides a comprehensive overview of the challenges and opportunities in managing chronic hepatitis B in children. It's a reminder that the fight against this disease requires continued research, innovative therapies, and a strong commitment to prevention. By embracing evidence-based practices and working together, we can create a healthier future for children and families affected by HBV.
Date :
  1. Date Completed 2014-12-01
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

24863185

DOI: Digital Object Identifier

10.1111/jgh.12550

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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