Role of platelet inhibitor therapy in myocardial infarction.

Author: FusterV, SteinB

Paper Details 
Original Abstract of the Article :
Atherosclerotic plaque disruption is the predominant pathogenetic mechanism underlying the acute coronary syndromes. Plaque rupture leads to the exposure of collagen and vessel media, resulting in platelet and clotting activation, and occlusive thrombus formation. While drugs that interfere with pla...See full text at original site
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引用元:
https://doi.org/10.1007/BF01869563

データ提供:米国国立医学図書館(NLM)

The Role of Platelet Inhibitors in Myocardial Infarction: A Desert Oasis for Cardiac Health

Cardiovascular disease, a vast and complex desert of health issues, is often marked by atherosclerotic plaque disruption, the culprit behind acute coronary syndromes. This disruption, like a sudden sandstorm, exposes collagen and vessel media, triggering a cascade of events – platelet and clotting activation, leading to occlusive thrombus formation, much like a sand dune slowly blocking a vital oasis.

This research dives into the heart of this desert, investigating the role of platelet inhibitors in managing myocardial infarction. The study employed a comprehensive review of existing literature, examining the pathogenesis of coronary thrombosis, the pharmacology of platelet-inhibitor agents, and their efficacy in treating patients with acute myocardial infarction and preventing cardiovascular disease.

The study found that aspirin, sulfinpyrazone, and dipyridamole, like reliable desert guides, have undergone extensive clinical testing in patients with cardiovascular disease. More recently, ticlopidine, a potent platelet inhibitor, has emerged as a promising new oasis in the vast landscape of treatment options. In acute myocardial infarction, aspirin significantly reduces cardiovascular mortality and reinfarction, like a refreshing oasis in the midst of a sandstorm.

Furthermore, the combination of aspirin and a thrombolytic agent produces maximal benefit. The study also highlighted the growing role of heparin in preventing early mortality and reinfarction, acting as a protective barrier against the onslaught of sandstorms.

Aspirin and Platelet Inhibition: A Protective Oasis in the Desert of Cardiovascular Disease

The study's findings suggest that aspirin, like a steadfast guardian of the oasis, plays a crucial role in both primary and secondary prevention of cardiovascular disease. Long-term anticoagulant therapy, though beneficial, is associated with high costs, extensive monitoring requirements, and a potential for hemorrhagic side effects, akin to the dangers of navigating a treacherous desert landscape.

Navigating the Desert of Cardiovascular Disease: A Guide for Maintaining Oasis Health

These findings underscore the importance of understanding and managing the complex interplay of platelets, coagulation, and fibrinolytic systems in the pathogenesis of thrombosis. It's like navigating a vast desert, where careful understanding of the terrain and its challenges is crucial to reaching a safe and healthy oasis.

Dr.Camel's Conclusion

This research offers a roadmap through the treacherous desert of cardiovascular disease, highlighting the crucial role of platelet inhibitors in managing myocardial infarction and preventing future events. It's a reminder that even in the most challenging of environments, like a vast desert, with careful planning and the right resources, we can reach a healthy oasis.

Date :
  1. Date Completed 1991-03-22
  2. Date Revised 2020-03-04
Further Info :

Pubmed ID

2487543

DOI: Digital Object Identifier

10.1007/BF01869563

Related Literature

SNS
PICO Info
in preparation
Languages

English

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