Paper Details 
Original Abstract of the Article :
This study examined effects of neonatal prochlorperazine in rats tested as adults in a variety of behaviors. The drug exposure impaired open field behavior during treatment neonatally. However, no differences in open field behavior were observed in adulthood. Adult females that had received drug wer...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元:
https://doi.org/10.1016/0736-5748(83)90028-X

データ提供:米国国立医学図書館(NLM)

A Journey Through the Brain: Investigating the Impact of Early Drug Exposure

[Developmental neurotoxicity] is a complex and often overlooked aspect of health. This study explores the long-term effects of early postnatal exposure to [prochlorperazine] in rats, examining its impact on various behaviors in adulthood. Imagine a traveler venturing into a vast desert, each stage of the journey representing a developmental stage, and the traveler carrying the weight of early exposure to prochlorperazine.

A Subtle Shift: Long-Term Effects of Early Drug Exposure

The study reveals that early exposure to prochlorperazine can lead to subtle changes in brain development, influencing behavioral patterns in adulthood. It's like a desert traveler navigating shifting sands, where early missteps can have lasting consequences. The authors emphasize the importance of understanding the potential risks of early drug exposure and the need for further research to elucidate the underlying mechanisms.

From the Lab to the Clinic: Implications for Human Development

The study highlights the potential impact of early drug exposure on human development, emphasizing the importance of careful consideration when prescribing medications to children. It's like a desert guide advising travelers to choose their paths wisely, considering the potential hazards and rewards of each route. The study encourages further research to better understand the long-term effects of medications on the developing brain.

Dr. Camel's Conclusion

This study underscores the importance of understanding the subtle yet profound impact of early drug exposure on brain development. It's a reminder that even seemingly minor interventions can have lasting consequences. The study encourages further research to guide the development of safer and more effective medications for children, minimizing the risks of developmental neurotoxicity.

Date :
  1. Date Completed 2014-06-02
  2. Date Revised 2020-01-06
Further Info :

Pubmed ID

24875944

DOI: Digital Object Identifier

10.1016/0736-5748(83)90028-X

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SNS
PICO Info
in preparation
Languages

English

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