A computational prospect to aspirin side effects: aspirin and COX-1 interaction analysis based on non-synonymous SNPs.

Author: HamzehMesrian Tanha, MarjanMojtabavi Naeini, RahmanEmamzadeh, SadeqVallian

Paper Details 
Original Abstract of the Article :
Aspirin (ASA) is a commonly used nonsteroidal anti-inflammatory drug (NSAID), which exerts its therapeutic effects through inhibition of cyclooxygenase (COX) isoform 2 (COX-2), while the inhibition of COX-1 by ASA leads to apparent side effects. In the present study, the relationship between COX-1 n...See full text at original site
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引用元:
https://doi.org/10.1016/j.compbiolchem.2014.05.002

データ提供:米国国立医学図書館(NLM)

Aspirin's Double-Edged Sword: A Computational Look

Aspirin, a common pain reliever, is like a trusty desert camel – reliable and helpful. But like any powerful tool, it has its limitations. This study delves into the potential for side effects caused by [aspirin] and its interaction with the [COX-1 enzyme]. It's like exploring a hidden cavern in the desert – a unique space with its own set of rules. The researchers used [computational analysis] to examine how individual variations in the [COX-1 gene] might influence the effectiveness and side effects of aspirin.

Tailoring Treatment: A New Frontier

The researchers identified specific [SNPs] – small variations in DNA – that could affect how aspirin interacts with COX-1. It's like finding different paths through a maze – each one leading to a unique outcome. The analysis suggests that some people might be more prone to side effects while others might benefit from aspirin's pain-relieving properties. This research opens a new avenue for personalized medicine – tailoring treatment based on individual genetic variations.

Finding Balance in Treatment

This study highlights the importance of understanding individual variations in response to medication. While aspirin is often a safe and effective treatment, this research reminds us that we need to be cautious and aware of potential side effects. As Dr. Camel says, "The desert is full of surprises. It's important to be prepared for the unexpected and always consider the individual needs of each traveler."

Dr.Camel's Conclusion

This research opens a new chapter in understanding the complex relationship between aspirin and individual genetic variations. It shows the promise of personalized medicine, where treatment is tailored to each patient's unique needs. This research reminds us that even in the vastness of the desert, we can find individual solutions to navigate the challenges we face.

Date :
  1. Date Completed 2015-05-12
  2. Date Revised 2014-08-04
Further Info :

Pubmed ID

24953043

DOI: Digital Object Identifier

10.1016/j.compbiolchem.2014.05.002

Related Literature

SNS
PICO Info
in preparation
Languages

English

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