Paper Details
- Home
- Paper Details
L-658,310, a new injectable cephalosporin. I. In vitro antibacterial properties.
Author: AbruzzoG K, FromtlingR A, GadebuschH H, GillC, PonticasS, ShunguD L, ValiantM E, WeissbergerB A
Original Abstract of the Article :
The in vitro antibacterial spectrum of L-658,310, a new semisynthetic cephalosporin, was compared with ceftazidime, aztreonam and piperacillin against a wide variety of randomly selected human clinical isolates. The compound was found to be a broad spectrum bactericidal agent that was more potent th...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.7164/antibiotics.42.795
データ提供:米国国立医学図書館(NLM)
Introducing L-658,310: A Novel Injectable Cephalosporin
This study delves into the realm of [antimicrobial drug development] – the investigation of a new semisynthetic cephalosporin, L-658,310, for its in vitro antibacterial properties. The study employed a [comparative analysis] approach to assess the antibacterial spectrum and potency of L-658,310 against a wide range of clinical isolates, comparing it to established antibiotics like ceftazidime, aztreonam, and piperacillin. The study found that L-658,310 demonstrated broad-spectrum bactericidal activity and exhibited superior potency against glucose nonfermenting bacteria, including multi-resistant strains of Pseudomonas aeruginosa. The researchers attributed this enhanced activity to the presence of dihydroxy substituents on the 2-methylisoindoline moiety of L-658,310.
A Promising New Cephalosporin: L-658,310
The findings highlight L-658,310 as a promising new cephalosporin with potent antibacterial activity, particularly against multi-resistant bacteria. This research underscores the need for continued development of novel antibiotics to combat the growing challenge of antimicrobial resistance.
Battling Antimicrobial Resistance: A Global Challenge
This study underscores the ongoing battle against antimicrobial resistance. Developing new antibiotics is crucial to ensure effective treatment options for bacterial infections. As a wise old camel, I've always said that we must stay vigilant in our fight against these tenacious microbes.
Dr.Camel's Conclusion
This study introduces L-658,310, a promising new cephalosporin with potent antibacterial activity. It highlights the importance of continued research in antimicrobial drug development to combat the growing threat of antimicrobial resistance.
Date :
- Date Completed 1989-06-30
- Date Revised 2019-07-23
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.