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Effects of anti-obesity drugs, phentermine and mahuang, on the behavioral patterns in Sprague-Dawley rat model.

Author: ChoiKyung-Chul, GoRyeo-Eun, HwangKyung-A, JeonSo-Ye, KimCho-Won, KimSeung-Hee, KimYun-Bae, LeeMin-Young

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Phentermine and Ephedra sinica (mahuang) are anti-obesity drugs that can cause behavioral changes in rats. In animal studies, these drugs were found to reduce motor ability, ability to cope with external stimuli, and sense of balance. They also increased wariness and excitement. These adverse effects need to be identified in humans and these drugs should be prescribed only when the benefits outweigh the risks.
Paper Details　
Original Abstract of the Article :
According to WHO global estimates from 2008, more than 1.4 billion adults were overweight and among them, over 200 million men and 300 million women were obese. Although the main treatment modalities for overweight and obese individuals remain dieting and physical exercise, the synthetic anti-obesit...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079834/

データ提供：米国国立医学図書館（NLM）

Unveiling the Behavioral Effects of Anti-Obesity Drugs

The global obesity epidemic presents a significant challenge to public health. While dieting and exercise are cornerstone treatments, anti-obesity medications are increasingly being used. This study investigates the behavioral effects of phentermine and mahuang, two commonly used anti-obesity drugs. Researchers conducted animal experiments to assess the impact of these drugs on locomotor activity, response to external stimuli, and balance. The results indicate that both drugs can induce significant behavioral changes, raising concerns about their potential side effects in humans.

Anti-Obesity Medications: A Double-Edged Sword?

The study revealed that both phentermine and mahuang can alter the behavioral patterns of rats, impacting their motor ability, response to external stimuli, and balance. While these drugs may hold promise for weight management, the potential behavioral side effects require careful consideration. The researchers emphasize the importance of balancing the potential benefits of anti-obesity medications with their risks.

A Wise Approach to Weight Management

Given the potential behavioral effects of anti-obesity drugs, it is essential to approach weight management with a holistic perspective. Lifestyle modifications, including diet and exercise, should be the primary focus, with medication considered as a supplementary approach. It's important to consult with a healthcare professional to determine the most appropriate treatment strategy based on individual needs and circumstances. Just as a camel navigates the harsh desert landscape, we must carefully consider the risks and benefits of various weight management approaches to find the path that leads to both physical and mental well-being.

Dr.Camel's Conclusion

This study provides a valuable reminder that anti-obesity medications, while potentially helpful, can also have significant side effects. It underscores the importance of comprehensive weight management strategies that address both physical and behavioral aspects of obesity. As with all medical interventions, a careful assessment of the risks and benefits is crucial before embarking on a treatment plan.
Date :
  1. Date Completed 2014-07-07
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24999361

DOI: Digital Object Identifier

PMC4079834

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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