Paper Details

  1. Home
  2. Paper Details

Prevention of alcohol withdrawal seizures with carbamazepine and valproic acid.

Author: HillbomM, KasteM, KuuselaV, Källi-LemmaL, KärkkäinenP, PilkeA, TokolaR

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Carbamazepine and sodium valproate were compared to placebo in 138 intoxicated alcoholics for alcohol withdrawal symptom prevention. Sodium valproate induced gastric distress, while carbamazepine caused intolerable side effects in half of the subjects. Both drugs had limited utility due to side effects.
Paper Details　
Original Abstract of the Article :
To evaluate the value of the nonsedative anticonvulsants carbamazepine and valproic acid a controlled study including drug monitoring was carried out. Intoxicated alcoholics (n = 138) were admitted for inpatient detoxication and randomly assigned to either carbamazepine (n = 43), sodium valproate (n...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0741-8329(89)90022-0

データ提供：米国国立医学図書館（NLM）

Preventing Alcohol Withdrawal Seizures: A Challenging Task

Alcohol withdrawal seizures are a serious health risk, and the quest for effective preventative measures is a priority for clinicians. This study investigates the efficacy of two nonsedative anticonvulsants, carbamazepine and valproic acid, in preventing alcohol withdrawal seizures. The researchers conducted a double-blind, placebo-controlled trial to evaluate the effectiveness of these medications. The results highlight the challenges associated with using these drugs for this purpose.

Limitations of Carbamazepine and Valproic Acid in Alcohol Withdrawal

The study revealed that carbamazepine and valproic acid, despite their potential benefits, were hindered by significant side effects that often led to discontinuation of treatment. The researchers found that about half of the participants had to stop taking carbamazepine due to adverse effects, and valproic acid caused gastrointestinal distress in many patients. The study concluded that the side-effect profile of these medications may limit their utility as routine treatments for preventing alcohol withdrawal seizures.

Navigating the Challenges of Alcohol Withdrawal

This study emphasizes the need for further research to identify effective and safe treatments for alcohol withdrawal. The findings underscore the complexities of managing alcohol withdrawal, a condition that requires a multifaceted approach. It’s essential to consider the individual patient’s needs and potential risks associated with different treatment options.

Dr.Camel's Conclusion

This research, much like the journey through the desert, is a reminder that there are challenges and obstacles along the way. The study shows that while carbamazepine and valproic acid have potential, their side effects pose a significant hurdle. We need to keep exploring new avenues to find more effective and safe solutions for preventing alcohol withdrawal seizures.

Date :
  1. Date Completed 1989-07-31
  2. Date Revised 2019-09-12
Further Info :

Pubmed ID

2500138

DOI: Digital Object Identifier

10.1016/0741-8329(89)90022-0

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.