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Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study.

Author: ChangI K, ImM, KimC D, LeeH E, LeeJ H, LeeY, SeoY J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A randomized, controlled comparative study evaluated the efficacy and tolerability of antihistamine as an adjuvant treatment of isotretinoin for acne. The study found that isotretinoin with additional antihistamine showed a more significant decrease in acne lesion counts and a lower frequency of acne flare. Side effects of isotretinoin were also more tolerable in the antihistamine group.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Isotretinoin has been frequently used for acne therapy. However, it has limitation in acceptance because of its adverse effects. Although antihistamine recently revealed to decrease the lipogenesis, evidence is lacking regarding the clinical relevance of antihistamine in the treatment of...See full text at original site
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引用元：
https://doi.org/10.1111/jdv.12403

データ提供：米国国立医学図書館（NLM）

A New Approach to Acne Treatment: Combining Isotretinoin with Antihistamine

In the vast and often challenging landscape of dermatology, finding effective treatments for acne is a constant quest. This study explores the potential of combining isotretinoin, a widely used acne medication, with an antihistamine, desloratadine, to enhance treatment outcomes. Researchers conducted a randomized, controlled comparative study, comparing the efficacy of this combination therapy to isotretinoin alone. The findings reveal that adding desloratadine to isotretinoin significantly improves acne lesion counts, reduces sebum production, and improves overall acne severity. This study offers a promising new approach for managing acne, potentially reducing the need for higher doses of isotretinoin and its associated side effects.

A Synergistic Approach to Acne Treatment

This research provides a compelling case for combining isotretinoin with an antihistamine, showcasing its potential to improve treatment outcomes and reduce the severity of acne. The study highlights the importance of exploring synergistic treatment strategies to enhance efficacy and minimize side effects.

Navigating the Terrain of Acne Treatment

While this study offers encouraging results, further research is needed to confirm these findings in larger populations and assess the long-term effects of this combination therapy. It's essential to individualize treatment plans based on the patient's specific needs and monitor for any potential side effects.

Dr. Camel's Conclusion

This research journey through the desert of acne treatment reveals a promising new approach that combines isotretinoin with an antihistamine. This discovery offers hope for individuals seeking effective and well-tolerated solutions for managing their acne.
Date :
  1. Date Completed 2015-07-09
  2. Date Revised 2014-11-21
Further Info :

Pubmed ID

25081735

DOI: Digital Object Identifier

10.1111/jdv.12403

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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