Paper Details

  1. Home
  2. Paper Details

Slow release delivery of rioprostil by an osmotic pump inhibits the formation of acute aspirin-induced gastric lesions in dogs and accelerates the healing of chronic lesions without incidence of side effects.

Author: KatzL B, ShriverD A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Rioprostil, a drug for treating gastric ulcers, was more potent and longer-acting when administered via an osmotic pump. The pump delivery effectively prevented aspirin-induced gastric lesions and healed pre-existing lesions. The drug was well tolerated at doses 935-2805 times the gastroprotective ED50.
Paper Details　
Original Abstract of the Article :
Rioprostil, a primary alcohol prostaglandin E1 analog, inhibits gastric acid secretion and prevents gastric lesions induced by a variety of irritants in experimental animals. Because rioprostil is relatively short-acting, it would be of significant benefit clinically if its duration of action could ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0041-008x(89)90209-3

データ提供：米国国立医学図書館（NLM）

Rioprostil Delivery for Preventing and Healing Gastric Lesions

This study ventures into the harsh landscape of [gastric lesions], a condition that can be as painful as a scorching desert wind. The researchers, armed with their knowledge of [prostaglandin E1 analogs] and [osmotic pumps], aim to find a safe and effective way to prevent and heal these lesions. Their findings offer a glimmer of hope for those suffering from these painful conditions.

Rioprostil Shows Promise in Gastric Lesion Management

The researchers found that [rioprostil delivered via an osmotic pump is effective in preventing and healing gastric lesions]. This discovery is like finding a cool spring of water in a barren desert, offering relief from the burning pain and discomfort of these lesions.

Potential for Improved Gastric Health

This study suggests that [rioprostil delivered via an osmotic pump could offer a new and effective way to manage gastric lesions], providing a potential pathway to improved gastric health. This discovery is like finding a new and resilient plant that can thrive even in the most arid environments, offering hope for a healthier future.

Dr.Camel's Conclusion

This study offers a promising approach to managing gastric lesions, highlighting the potential of rioprostil delivered via an osmotic pump as a safe and effective treatment option. This research is like finding a hidden oasis in the desert, offering a haven from the harsh realities of gastric lesions and the potential for a healthier future.

Date :
  1. Date Completed 1989-11-14
  2. Date Revised 2019-07-27
Further Info :

Pubmed ID

2508266

DOI: Digital Object Identifier

10.1016/0041-008x(89)90209-3

Related Literature

Article Analysis
・Side Effects of aspirin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.