Paper Details

  1. Home
  2. Paper Details

A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement.

Author: AlshrydaS, BlenkinsoppJ, HaddadF S, MasonJ M, SardaP, SukeikM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and meta-analysis evaluated the efficacy and safety of topical tranexamic acid (TXA) in reducing blood loss and the need for transfusion after total knee and hip replacement. Topical TXA was found to significantly reduce the rate of blood transfusion compared to placebo, with no increase in thromboembolic events. The review suggests that topical TXA is an effective and safe method for reducing transfusion needs, potentially superior to intravenous administration.
Paper Details　
Original Abstract of the Article :
Intravenous tranexamic acid (TXA) has been shown to be effective in reducing blood loss and the need for transfusion after joint replacement. Recently, there has been interest in applying it topically before the closure of surgical wounds. This has the advantages of ease of application, maximum conc...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1302/0301-620X.96B8.33745

データ提供：米国国立医学図書館（NLM）

Topical Tranexamic Acid: A New Frontier in Reducing Blood Loss After Joint Replacement

Joint replacement surgery can be associated with significant blood loss, often leading to the need for blood transfusions. This study investigated the effectiveness of topical tranexamic acid (TXA) in reducing blood loss and transfusion rates after total hip and knee replacement surgery. The researchers conducted a systematic review and meta-analysis of 14 randomized controlled trials, finding that topical TXA significantly reduced the need for blood transfusions compared to placebo.

Topical TXA: A Safe and Effective Alternative

The study's findings suggest that topical TXA is an effective and safe method for reducing blood loss and transfusion rates after joint replacement surgery. The researchers highlight the advantages of topical TXA, including ease of application, maximum concentration at the site of bleeding, and minimal systemic absorption.

Joint Replacement Surgery: A Journey Through Recovery

Joint replacement surgery can be a challenging journey, with the potential for significant blood loss. This research offers a potential oasis of relief, providing a new and promising approach to minimizing blood loss and improving recovery outcomes.

Dr.Camel's Conclusion

The desert of joint replacement surgery can be a challenging trek, with potential for blood loss like a hidden oasis of danger. This research provides a new tool for managing blood loss, offering a safer and more effective alternative to traditional approaches.

Date :
  1. Date Completed 2014-09-25
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

25086114

DOI: Digital Object Identifier

10.1302/0301-620X.96B8.33745

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.