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Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.

Author: , BestJames D, JenkinsAlicia J, KeechAnthony C, LiLiping, MannKristy P, ParkKris, SaltevoJuha, StuckeyBronwyn G A, ZanninoDiana, d'EmdenMichael C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Fenofibrate improved the lipoprotein profile more in women than men. However, the reduction in cardiovascular events was similar in both sexes, suggesting that fenofibrate therapy should be considered for cardioprotection in both women and men with type 2 diabetes.
Paper Details　
Original Abstract of the Article :
AIMS/HYPOTHESIS: In the double-blind placebo-controlled Fenofibrate Intervention and Event Lowering in Diabetes trial (n = 9,795), fenofibrate reduced major cardiovascular events in type 2 diabetes. Sex-related differences in fenofibrate response could be clinically relevant and were pre-specified a...See full text at original site
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引用元：
https://doi.org/10.1007/s00125-014-3344-3

データ提供：米国国立医学図書館（NLM）

Fenofibrate for Cardiovascular Protection in Women with Type 2 Diabetes

Type 2 diabetes is a chronic condition that significantly increases the risk of cardiovascular disease. This research examines the effects of fenofibrate, a medication that helps regulate lipid levels, in a large-scale, double-blind, placebo-controlled trial involving patients with type 2 diabetes. The study specifically focuses on sex-related differences in the response to fenofibrate, exploring its impact on lipoproteins and cardiovascular events.

Fenofibrate's Beneficial Effects on Lipids and Cardiovascular Health

The results showed that fenofibrate significantly improved lipid profiles in both men and women, with a greater reduction in total, LDL, and non-HDL cholesterol in women. Importantly, fenofibrate reduced the risk of total cardiovascular events by 30% in women and 13% in men, suggesting a potential benefit for both sexes. These findings support the use of fenofibrate for cardioprotection in both men and women with type 2 diabetes.

Understanding the Impact of Fenofibrate on Cardiovascular Health

This research highlights the importance of personalized medicine, recognizing the distinct responses to medications based on individual characteristics such as sex. It emphasizes the need for careful consideration of fenofibrate therapy for cardioprotection in both men and women with type 2 diabetes, taking into account individual risk factors and lipid profiles. The study also suggests that further research is needed to understand the underlying mechanisms responsible for the sex-specific differences observed in fenofibrate's effects.

Dr.Camel's Conclusion

Think of type 2 diabetes as a desert oasis where the balance of lipids is crucial for maintaining health. Fenofibrate, like a carefully chosen plant, can help regulate this balance, offering protection against the risk of cardiovascular disease. This research suggests that fenofibrate might be particularly beneficial for women with type 2 diabetes, reminding us that each person's journey through the desert of chronic illness requires unique strategies for optimal health.

Date :
  1. Date Completed 2015-07-06
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

25149070

DOI: Digital Object Identifier

10.1007/s00125-014-3344-3

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Languages

English

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