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Gestrinone versus danazol in the treatment of endometriosis.

Author: ArcainiL, BianchiS, CandianiG B, FedeleL, ViezzoliT

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared gestrinone and danazol for treating infertility caused by endometriosis in 39 patients. Both treatments improved pain symptoms and reduced endometriosis severity, with no significant differences between the groups. After 18 months, pregnancy rates were similar, at 33% for gestrinone and 40% for danazol. While pain symptoms returned in a similar percentage of patients in both groups, side effects were more common and severe with danazol, while gestrinone primarily caused weight gain and acne. The study suggests that gestrinone is as effective as danazol for treating endometriosis-related infertility and may be better tolerated.
Paper Details　
Original Abstract of the Article :
Thirty-nine infertile patients with laparoscopic diagnosis of endometriosis were allocated randomly to treatment with gestrinone 2.5 mg twice weekly (20 patients) or danazol 600 mg/day (19 patients) for 6 months. If amenorrhea was not obtained after 1 month of treatment, the gestrinone dose was incr...See full text at original site
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引用元：
https://doi.org/10.1016/s0015-0282(16)60666-0

データ提供：米国国立医学図書館（NLM）

Gestrinone vs. Danazol: A Duel in the Desert of Endometriosis

The world of infertility is a vast and complex desert, with endometriosis, a condition that can affect fertility, being a common challenge. This study compares the effectiveness of gestrinone and danazol, two medications used to treat endometriosis. It's like comparing two different camel caravans, each offering a unique approach to navigating the challenges of this desert. The study found that gestrinone was as effective as danazol in treating infertility associated with endometriosis, but it was better tolerated. This is like finding a caravan that travels a smoother and more comfortable route, offering a better experience for those seeking relief from the challenges of the desert.

Gestrinone: A Smoother Path Through the Desert of Endometriosis

The study suggests that gestrinone might be a preferred treatment option for endometriosis, providing similar effectiveness to danazol but with fewer side effects. This is like finding a caravan that offers a more comfortable and pleasant journey through the desert, minimizing the discomfort and challenges of the terrain. However, the authors note that more research is needed to fully understand the long-term effects of gestrinone and to optimize its use in treating endometriosis.

Navigating the Desert of Infertility

This research highlights the importance of carefully considering treatment options for endometriosis, taking into account both effectiveness and tolerability. It's like navigating the vast desert of infertility, choosing the best caravan and route to reach the desired destination. The authors encourage ongoing research and development of new and improved treatments for endometriosis, ensuring that patients have access to the best possible care.

Dr.Camel's Conclusion

This study compares gestrinone and danazol for treating endometriosis, suggesting that gestrinone may be a better option due to its improved tolerability. It's like choosing a camel caravan that offers a smoother and more comfortable journey through the challenging terrain of endometriosis.

Date :
  1. Date Completed 1989-06-07
  2. Date Revised 2019-07-07
Further Info :

Pubmed ID

2523321

DOI: Digital Object Identifier

10.1016/s0015-0282(16)60666-0

Related Literature

Article Analysis
・Effective treatment of endometriosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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