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[ALK-rearranged non-small cell lung cancer: how to optimize treatment with crizotinib in routine practice?].

Author: Audigier-ValetteClarisse, BarlesiFabrice, CadranelJacques, CortotAlexis B, DebieuvreDidier, GirardNicolas, MennecierBertrand, Moro-SibilotDenis, PlanchardDavid, ZalcmanGérard

Consensus Development ConferenceA conference organized by the National Institutes of Health (NIH) to develop consensus and recommendations on medical issues.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Crizotinib, a tyrosine kinase inhibitor, is used for ALK-rearranged lung cancer. This review provides practical guidelines to optimize crizotinib tolerability, focusing on managing visual disturbances, cardiac effects, liver issues, and hypogonadism.
Paper Details　
Original Abstract of the Article :
Crizotinib (XALKORI(™), Pfizer) is a tyrosine kinase inhibitor of ALK, MET, and ROS1, which is currently approved for the second line treatment for ALK-rearranged lung cancer. This work from an expert group, based on the review of the data from the Profile studies, aims to provide practical elements...See full text at original site
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引用元：
https://doi.org/10.1684/bdc.2014.1976

データ提供：米国国立医学図書館（NLM）

Optimizing Treatment with Crizotinib for ALK-Rearranged Lung Cancer

The world of oncology is constantly evolving, and finding the best treatment for lung cancer is like searching for a rare oasis in a vast desert. This research focuses on optimizing the treatment of ALK-rearranged non-small cell lung cancer with crizotinib, a tyrosine kinase inhibitor. This study delves into the practical aspects of managing the side effects associated with this treatment, which can be as challenging as navigating a sandstorm.

Understanding the Side Effects of Crizotinib

The researchers, like seasoned desert explorers, have mapped out the common side effects of crizotinib. These include visual disturbances, heart-related issues, elevated liver enzymes, and hormonal imbalances. The study emphasizes the importance of being aware of these side effects, especially visual disturbances, which can be a real challenge for those who need to drive.

Managing the Side Effects: A Desert Guide

The research team, like expert guides, provides tips on managing these side effects. For instance, they recommend regular ECGs to monitor for heart rhythm changes and close monitoring of liver function tests. In addition, they highlight the potential for hormonal imbalances, emphasizing the need for testosterone testing in patients experiencing fatigue or depression.

Dr.Camel's Conclusion

This research is a beacon of hope for patients with ALK-rearranged lung cancer, offering practical insights into managing the side effects of crizotinib treatment. Like the enduring resilience of camels, patients can find ways to adapt and overcome the challenges posed by this medication, paving the way for improved treatment outcomes.

Date :
  1. Date Completed 2015-03-27
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25299566

DOI: Digital Object Identifier

10.1684/bdc.2014.1976

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Article Analysis
・Side Effects of crizotinib
SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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