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Development of a biocompatible nanodelivery system for tuberculosis drugs based on isoniazid-Mg/Al layered double hydroxide.

Author: ArulselvanPalanisamy, El ZowalatyMohamed Ezzat, FakuraziSharida, GeilichBenjamin M, HusseinMohd Zobir, SaifullahBullo, WebsterThomas J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study presents a novel nanodelivery system for isoniazid, an anti-TB drug, that achieves sustained release in simulated human conditions and demonstrates high biocompatibility and efficacy against Mycobacterium tuberculosis.
Paper Details　
Original Abstract of the Article :
The primary challenge in finding a treatment for tuberculosis (TB) is patient non-compliance to treatment due to long treatment duration, high dosing frequency, and adverse effects of anti-TB drugs. This study reports on the development of a nanodelivery system that intercalates the anti-TB drug iso...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200032/

データ提供：米国国立医学図書館（NLM）

A Biocompatible Nanodelivery System for Tuberculosis Drugs

This research focuses on the development of a novel nanodelivery system for tuberculosis (TB) drugs, aiming to address the challenges of patient non-compliance. The authors developed a system based on isoniazid-Mg/Al layered double hydroxides (LDHs), aiming for sustained drug release and improved patient tolerability.

Sustained Release and Enhanced Biocompatibility

The study demonstrated that the nanodelivery system successfully intercalated isoniazid into the LDHs and released it in a sustained manner. Furthermore, the researchers found the formulation to be highly biocompatible compared to free isoniazid, showing promising results in human lung and mouse fibroblast cells.

Potential for Improved TB Treatment

The study's findings suggest that the nanodelivery system could lead to improved treatment outcomes for TB. The sustained release of isoniazid could enhance patient compliance and reduce the frequency of dosing. The formulation's biocompatibility suggests that it could minimize adverse effects, further contributing to patient adherence.

Dr.Camel's Conclusion

This research offers a glimmer of hope in the fight against TB. By utilizing the power of nanotechnology, the authors have developed a promising drug delivery system that could address key challenges in TB treatment. Like a camel carrying precious water across the arid landscape, this nanodelivery system could deliver hope and healing to patients suffering from this debilitating disease.
Date :
  1. Date Completed 2015-06-02
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

25336952

DOI: Digital Object Identifier

PMC4200032

SNS
PICO Info
in preparation
Languages

English

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