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Long Term Stability Evaluation of Prostacyclin Released from Biomedical Device through Turbiscan Lab Expert.

Author: BarbacaneRenato C, CarafaMaria, CeliaChristian, CilurzoFelisa, CoscoDonato, Di MarzioLuisa, FleuryMathias, FrestaMassimo, GentileEmanuela, LocatelliMarcello, PaolinoDonatella, ScaliseDaniela, TisserandChristelle, VenturaCinzia Anna

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the long-term stability of Iloprost isotonic solution in biomedical devices using Turbiscan technology. The study found that Iloprost isotonic solution is stable in biomedical devices and can be used for long-term drug delivery.
Paper Details　
Original Abstract of the Article :
Therapeutic guidelines indicate prostacyclin as the first line of treatment in inflammation and vascular diseases. Prostacyclins prevent formation of the platelet plug involved in primary hemostasis by inhibiting platelet activation and, combined with thromboxane, are effective vasodilators in vascu...See full text at original site
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引用元：
https://doi.org/10.2174/1573406410666141110153502

データ提供：米国国立医学図書館（NLM）

Prostacyclin: A Lifeline in the Desert of Vascular Disease

Peripheral arterial disease (PAD), a condition that affects blood flow in the arteries, can be a challenging journey, often leading to pain, fatigue, and even amputation. Prostacyclin, a powerful vasodilator and platelet inhibitor, has emerged as a key player in managing PAD, but its effectiveness is often hampered by its short half-life, requiring frequent administration.

Biomedical Devices: A New Oasis for Prostacyclin Delivery

This research explores the potential of biomedical devices, specifically elastomeric pumps, for delivering prostacyclin over extended periods. The study investigated the long-term stability of prostacyclin in these devices using Turbiscan technology, a technique that measures backscattering and transmission of light to assess the stability of suspensions, emulsions, and colloidal formulations.

Sustainable Delivery: A Path Through the Desert

The findings suggest that biomedical devices can provide a sustainable and effective way to deliver prostacyclin, potentially improving patient compliance and reducing the need for frequent intravenous infusions. This innovation could revolutionize the treatment of PAD, offering a more convenient and effective approach to managing this challenging condition.

Dr. Camel's Conclusion

This research, like a caravan crossing a vast desert, reveals a promising new approach to delivering prostacyclin for the treatment of PAD. Biomedical devices offer a potentially more effective and sustainable method of administering this vital medication, improving patient comfort and treatment outcomes. This research is a reminder that innovation and a commitment to improving patient care can lead to transformative breakthroughs in the fight against vascular disease.
Date :
  1. Date Completed 2016-02-01
  2. Date Revised 2019-10-27
Further Info :

Pubmed ID

25381994

DOI: Digital Object Identifier

10.2174/1573406410666141110153502

Related Literature

Article Analysis
・Side Effects of iloprost
SNS
PICO Info
in preparation
Languages

English

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