Paper Details

  1. Home
  2. Paper Details

Phosphonate analogues of 1α, 25 dihydroxyvitamin D3 are promising candidates for antitumoural therapies.

Author: CurinoA C, FacchinettiM M, FerronatoM J, GrioliS M, MascaroE, RadivoyG E, SalomónD G, VitaleC A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the effects and potential application in cancer of vitamin D and its derivatives, with an emphasis on phosphonate analogues. A new vitamin D analogue (EM1) with potent antiproliferative effects in various tumor cell lines, even those resistant to calcitriol treatment, has been synthesized. EM1 does not show toxic effects in animals, even at high doses and for extended periods of time.
Paper Details　
Original Abstract of the Article :
The active metabolite of vitamin D, 1α, 25 dihydroxyvitamin D3 (calcitriol) is classically known to regulate calcium and phosphate homeostasis and bon...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.2174/1568026615666141208101418

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2015-08-20
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

25486937

DOI: Digital Object Identifier

10.2174/1568026615666141208101418

Related Literature

Article Analysis
・Side Effects of calcitriol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.