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Naloxegol , a new drug for the treatment of opioid-induced constipation.

Author: CorsettiMaura, TackJan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Naloxegol, an orally administered, peripherally acting, μ-opioid receptor antagonist, was developed for the treatment of opioid-induced constipation.
Paper Details　
Original Abstract of the Article :
With increasing chronic opioid use, opioid-induced constipation (OIC) is becoming a relevant clinical challenge. Presently, only few treatments have been demonstrated to be more effective than placebo in treating OIC but most of them have a restricted clinical application because of side effects. Na...See full text at original site
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引用元：
https://doi.org/10.1517/14656566.2015.991306

データ提供：米国国立医学図書館（NLM）

Naloxegol: A New Hope for Opioid-Induced Constipation

This study focuses on naloxegol, a new drug for the treatment of opioid-induced constipation (OIC), a common and often challenging side effect of chronic opioid use.

Imagine a desert traveler who encounters a blockage in the path, hindering their journey. Opioids, while beneficial for pain management, can cause constipation, creating a similar blockage in the body's digestive system. This study explores a new solution for this common problem.

Naloxegol: A Targeted Approach to Relieve Constipation

Naloxegol, a peripherally acting μ-opioid receptor antagonist (PAMORA), is specifically designed to alleviate constipation without affecting the pain-relieving effects of opioids. The drug works by blocking opioid receptors in the gut, promoting bowel motility and relieving constipation.

A Promising Solution for a Common Problem

The study highlights the significant unmet need for effective treatments for OIC and suggests that naloxegol could offer a promising solution. Its targeted mechanism of action and potential for improved efficacy and tolerability make it a valuable addition to the treatment options for OIC.

Dr. Camel's Conclusion

This study introduces naloxegol, a new drug for the treatment of opioid-induced constipation. Its targeted mechanism of action offers hope for a more effective and tolerable treatment option, improving the quality of life for patients suffering from OIC.

Date :
  1. Date Completed 2015-05-18
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25496063

DOI: Digital Object Identifier

10.1517/14656566.2015.991306

Related Literature

Article Analysis
・Side Effects of naloxegol
SNS
PICO Info
in preparation
Languages

English

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