Paper Details

  1. Home
  2. Paper Details

Balancing benefits and harms of treatments for acute bipolar depression.

Author: CalabreseJoseph R, CitromeLeslie, Dell'OssoBernardo, FryeMark A, KetterTerence A, MillerShefali

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article assessed the number needed to treat (NNT) and the number needed to harm (NNH) for acute bipolar depression treatments. The study found that older FDA-approved treatments were efficacious but also associated with harms. Lamotrigine and antidepressants tended to be well-tolerated but had inadequate efficacy. Lurasidone was both efficacious and well-tolerated.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Bipolar depression is more pervasive than mania, but has fewer evidence-based treatments. METHODS: Using data from multicenter, randomized, double-blind, placebo-controlled trials and meta-analyses, we assessed the number needed to treat (NNT) for response and the number needed to harm ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/S0165-0327(14)70006-0

データ提供：米国国立医学図書館（NLM）

Bipolar Depression Treatment: Balancing Benefits and Risks

Bipolar depression is a challenging condition, like a desert with unpredictable weather patterns. This research explores the benefits and harms of different treatment options, aiming to help patients find the most effective path for managing their condition. The authors analyze the effectiveness of older and newer treatments for bipolar depression, comparing their efficacy and side effect profiles. This study delves into the complex landscape of bipolar depression treatment, seeking to navigate the balance between benefits and risks.

Finding the Right Oasis: Navigating the Desert of Bipolar Depression

The research highlights the importance of considering both the benefits and risks of different treatment options. While older medications may offer rapid relief, they often come with significant side effects. Newer medications show promise for better tolerability, but their long-term effectiveness is still being studied. Understanding the potential benefits and harms is crucial for making informed decisions about treatment.

Navigating the Desert: A Personalized Approach to Bipolar Depression

The journey through the desert of bipolar depression requires a personalized approach, considering individual needs and preferences. Working closely with a healthcare professional to assess the potential benefits and risks of different treatment options is crucial in finding the right path for each patient. Understanding the complexities of bipolar depression and its treatment is vital in navigating this challenging landscape.

Dr.Camel's Conclusion

This research offers valuable insights into the complexities of bipolar depression treatment. By carefully considering the benefits and harms of different treatment options, patients can work with their healthcare providers to find the most effective and safe path for managing their condition. It's a reminder that the journey through the desert of bipolar depression requires a personalized approach and a thorough understanding of the available options.

Date :
  1. Date Completed 2015-03-15
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

25533911

DOI: Digital Object Identifier

10.1016/S0165-0327(14)70006-0

Related Literature

Article Analysis
・Side Effects of armodafinil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.