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Could in-vitro studies on Ishikawa cell lines explain the endometrial safety of raloxifene? Systematic literature review and starting points for future oncological research.

Author: D'AntonaDonato, Di GangiStefania, GizzoSalvatore, LittaPietro, NardelliGiovanni Battista, NoventaMarco, SaccardiCarlo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study reviewed the in vitro mechanisms of action of raloxifene (RAL), a selective estrogen receptor modulator, on endometrial cells. RAL appears to induce apoptosis, inhibit estrogen-related cell proliferation, and reduce endometrial carcinogenesis.
Paper Details　
Original Abstract of the Article :
To evaluate all the in-vitro raloxifene (RAL) mechanisms of action on normal, Ishikawa, and different endometrium-derived cell lines to explain the in-vivo RAL endometrial effects, a systematic literature search was performed in the electronic databases MEDLINE, EMBASE ScienceDirect, and the Cochran...See full text at original site
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引用元：
https://doi.org/10.1097/CEJ.0000000000000107

データ提供：米国国立医学図書館（NLM）

Endometrial Safety of Raloxifene: A Systematic Literature Review

Raloxifene (RAL), a selective estrogen receptor modulator (SERM), is used to treat osteoporosis and prevent breast cancer. This systematic literature review examines in vitro studies on raloxifene's effects on endometrial cells to evaluate its endometrial safety profile. The researchers analyzed studies on Ishikawa cell lines and other endometrial-derived cell lines to assess RAL's potential impact on normal and cancerous endometrial tissue.

Evaluating the Endometrial Safety of Raloxifene

The review suggests that RAL may have a favorable endometrial safety profile, demonstrating antiproliferative and pro-apoptotic effects on endometrial cells. These findings support the use of RAL as a potentially safer alternative to tamoxifen in certain breast cancer patients.

Finding a Balance in the Desert of Estrogen Receptor Modulation: A Safer Approach

SERMs like RAL offer a potential therapeutic strategy for treating osteoporosis and breast cancer. This review provides valuable insights into RAL's endometrial safety profile, highlighting its potential as a safer alternative to tamoxifen in certain patient groups. Continued research is crucial to further evaluate the long-term effects and optimize the use of RAL.

Dr.Camel's Conclusion

This systematic review provides a comprehensive overview of in vitro studies on raloxifene's effects on endometrial cells. It supports the potential of RAL as a safer alternative to tamoxifen for certain breast cancer patients, emphasizing the need for further research to confirm its long-term safety and efficacy.

Date :
  1. Date Completed 2016-07-07
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25536299

DOI: Digital Object Identifier

10.1097/CEJ.0000000000000107

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Languages

English

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