Paper Details

  1. Home
  2. Paper Details

Feasibility study of colestipol as an oral phosphate binder in hemodialysis patients.

Author: HoodChristopher J, KamAngela L, Kendrik-JonesJamie C, MarshallMark R, WolleyMartin J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the phosphate-binding effects of colestipol, a bile acid sequestrant. The study aimed to assess colestipol's potential as a phosphate binder, considering the limitations of current calcium- and aluminium-based binders, and its potential cost-effectiveness.
Paper Details　
Original Abstract of the Article :
Currently available calcium- and aluminium-based phosphate binders are dose limited because of potential toxicity, and newer proprietary phosphate binders are expensive. We examined phosphate-binding effects of the bile acid sequestrant colestipol, a non-proprietary drug that is in the same class as...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/nep.12388

データ提供：米国国立医学図書館（NLM）

Exploring Colestipol as a Phosphate Binder in Hemodialysis Patients

In the vast desert of renal disease research, finding effective phosphate binders is a significant challenge. This study embarks on a journey to investigate the potential of colestipol, a bile acid sequestrant, as a phosphate binder for hemodialysis patients. Using a scientific approach, the researchers aimed to uncover the phosphate-binding properties of colestipol and compare its effectiveness to existing treatments. Their findings suggest that colestipol, a non-proprietary drug, holds promise as a cost-effective alternative to currently available phosphate binders.

The Promise of Colestipol

The study reveals that colestipol exhibits significant phosphate-binding abilities, comparable to sevelamer, a well-established phosphate binder. This discovery suggests a potential avenue for addressing the limitations of existing calcium- and aluminum-based binders, which are often associated with toxicity. Additionally, colestipol's non-proprietary status could make it a more affordable option for patients.

Benefits for Hemodialysis Patients

Colestipol, if proven effective in larger trials, could provide a much-needed relief for hemodialysis patients struggling with hyperphosphatemia. This could lead to improved overall health and quality of life, reducing the burden of treatment and associated complications. As a wise camel traversing the desert, I urge patients to discuss this promising development with their healthcare providers and explore the potential benefits of colestipol.

Dr.Camel's Conclusion

This study sheds light on a potential new path in the management of hyperphosphatemia for hemodialysis patients. Colestipol's promising phosphate-binding properties and its non-proprietary nature offer a beacon of hope in the vast landscape of renal care. Further research is essential to confirm these findings and explore the full therapeutic potential of colestipol.

Date :
  1. Date Completed 2015-12-21
  2. Date Revised 2015-03-26
Further Info :

Pubmed ID

25557531

DOI: Digital Object Identifier

10.1111/nep.12388

Related Literature

Article Analysis
・Side Effects of colestipol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.