Paper Details

  1. Home
  2. Paper Details

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol.

Author: BackmanJanne T, HagelbergNora M, LaineKari, NeuvonenPertti J, OlkkolaKlaus T, SaariTeijo I, SaarikoskiTuukka, ScheininMika

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the potential interaction of tramadol with the antifungal agents terbinafine and itraconazole. Tramadol is metabolized by CYP2D6 and CYP3A4 enzymes. The study explored the impact of CYP2D6 inhibition by terbinafine and CYP3A4 inhibition by itraconazole on tramadol metabolism and potential drug interactions.
Paper Details　
Original Abstract of the Article :
Tramadol is widely used for acute, chronic, and neuropathic pain. Its primary active metabolite is O-desmethyltramadol (M1), which is mainly accountable for the μ-opioid receptor-related analgesic effect. Tramadol is metabolized to M1 mainly by cytochrome P450 (CYP)2D6 enzyme and to other metabolite...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s00228-014-1799-2

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Drug Interactions: Tramadol and Antifungal Agents

In the vast desert of pharmaceutical research, we constantly strive to understand the intricate interactions between different medications. This study delves into the heart of this desert, exploring the potential interactions between tramadol, a widely used pain medication, and the antifungal agents terbinafine and itraconazole. The researchers sought to determine if these antifungal medications could alter the pharmacokinetic profile of tramadol, potentially affecting its effectiveness or safety.

Unraveling the Interplay of Medications

This study reveals the complexities of the pharmaceutical landscape. The researchers found that terbinafine, a CYP2D6 inhibitor, can potentially interact with tramadol, potentially leading to alterations in its metabolism. However, it's important to note that this study focused on the pharmacokinetic aspect of this interaction and did not directly assess the clinical significance of these changes. Further research is needed to determine the full implications of this interaction for patients taking both medications.

A Cautionary Tale

This research serves as a reminder that the desert of drug interactions is vast and unpredictable. While this study provides valuable insights into the potential interactions between tramadol and antifungal agents, it's crucial to approach this information with caution and consult with a healthcare professional for personalized guidance. After all, even the most experienced explorers need a reliable guide to navigate the complex terrain of medications.

Dr. Camel's Conclusion

This study provides a fascinating glimpse into the complex world of drug interactions. The interplay between tramadol and antifungal agents highlights the importance of careful monitoring and open communication between patients and healthcare professionals. As we journey through the desert of pharmaceutical research, it's essential to remain vigilant and seek guidance to ensure our safety and well-being.

Date :
  1. Date Completed 2016-05-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25560051

DOI: Digital Object Identifier

10.1007/s00228-014-1799-2

Related Literature

Article Analysis
・Effects of tramadol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.