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Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.

Author: BannuruRaveendhara R, KentDavid M, McAlindonTimothy E, SchmidChristopher H, VaysbrotElizaveta E, WongJohn B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This network meta-analysis found that intra-articular treatments were superior to nonsteroidal anti-inflammatory drugs for treating knee osteoarthritis (OA). Small but robust differences were observed between active treatments. All treatments except acetaminophen showed clinically significant improvement from baseline pain.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The relative efficacy of available treatments of knee osteoarthritis (OA) must be determined for rational treatment algorithms to be formulated. PURPOSE: To examine the efficacy of treatments of primary knee OA using a network meta-analysis design, which estimates relative effects of al...See full text at original site
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引用元：
https://doi.org/10.7326/M14-1231

データ提供：米国国立医学図書館（NLM）

Knee Osteoarthritis: A Comprehensive Look at Treatment Options

Knee osteoarthritis (OA) is a common condition that can cause pain, stiffness, and limited mobility. Researchers continue to investigate the effectiveness of various treatment options for knee OA. In this systematic review and network meta-analysis, researchers compared the efficacy of different pharmacologic interventions for knee OA. Like a camel navigating a vast desert of treatment options, researchers aimed to find the most effective path to relief for individuals with knee OA. The study found that intra-articular treatments, such as hyaluronic acid, were superior to nonsteroidal anti-inflammatory drugs (NSAIDs) for pain relief. This study provides valuable insights into the relative effectiveness of different treatments for knee OA.

Intra-Articular Treatments: A Potential Advantage for Knee OA

The study suggests that intra-articular treatments, particularly hyaluronic acid, may offer a more effective approach to pain relief in knee OA compared to NSAIDs.

Navigating the Desert of Knee OA Treatment

If you are living with knee OA, it's essential to discuss treatment options with your doctor. They can help you determine the best approach for your individual needs, taking into account factors like pain severity, functional limitations, and overall health.

Dr.Camel's Conclusion

This comprehensive review provides a valuable resource for understanding the relative effectiveness of different treatment options for knee OA. It highlights the potential benefits of intra-articular treatments, emphasizing the need for individualized treatment plans based on patient-specific factors.

Date :
  1. Date Completed 2015-03-16
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

25560713

DOI: Digital Object Identifier

10.7326/M14-1231

Related Literature

Article Analysis
・Effective treatment of osteoarthritis
SNS
PICO Info
in preparation
Languages

English

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