Paper Details

  1. Home
  2. Paper Details

Comparison of the Immunogenicity of Various Booster Doses of Inactivated Polio Vaccine Delivered Intradermally Versus Intramuscularly to HIV-Infected Adults.

Author: BeydounHind, ChumakovKonstantin, KhardoriNancy, KochbaEfrat, KouiavskaiaDiana, LevinYotam, MaldonadoYvonne, MirochnitchenkoOlga, SiikJulia, TroyStephanie B

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study explores the potential of intradermal inactivated polio vaccine (IPV) as a cost-effective alternative for global polio eradication. While intradermal IPV holds promise due to its potential for lower effective doses, previous studies using 20% of the standard intramuscular dose resulted in inferior antibody titers.
Paper Details　
Original Abstract of the Article :
Inactivated polio vaccine (IPV) is necessary for global polio eradication because oral polio vaccine can rarely cause poliomyelitis as it mutates and may fail to provide adequate immunity in immunocompromised populations. However, IPV is unaffordable for many developing countries. Intradermal IPV sh...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539908/

データ提供：米国国立医学図書館（NLM）

Intradermal Inactivated Polio Vaccine: A Promising Approach to Global Polio Eradication

The eradication of polio is a global health priority. Inactivated polio vaccine (IPV) is an essential part of polio eradication efforts. This study investigates the immunogenicity of various booster doses of IPV delivered intradermally compared to intramuscularly in HIV-infected adults. The researchers found that intradermal IPV, using a reduced dose compared to intramuscular IPV, elicited comparable antibody titers. This finding suggests that intradermal IPV could be a cost-effective and efficient way to administer IPV, particularly in resource-limited settings. The research provides valuable insights into the potential of intradermal IPV to contribute to global polio eradication efforts.

Intradermal IPV: A Potential Game-Changer for Polio Eradication

The study's findings suggest that intradermal IPV could be a transformative approach to polio eradication. Its ability to deliver effective immunity with a reduced dose makes it a promising option for global health initiatives.

Expanding Access to Polio Vaccination

This research highlights the importance of developing innovative approaches to vaccination, particularly in resource-limited settings. The potential of intradermal IPV to improve access to polio vaccination is a significant step forward in the fight against this debilitating disease.

Dr. Camel's Conclusion

This study offers a ray of hope for the eradication of polio. The potential of intradermal IPV to improve vaccine delivery and expand access to immunization is a testament to the power of innovation and collaboration in global health. This research holds promise for a future free from polio.

Date :
  1. Date Completed 2015-08-03
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

25567841

DOI: Digital Object Identifier

PMC4539908

Related Literature

Article Analysis
・Side Effects of polio vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.