Paper Details

  1. Home
  2. Paper Details

Systematic review and meta-analysis of the survival outcomes of first-line treatment options in high-risk prostate cancer.

Author: CaiYing C, CaoDe H, HanPing, LeiJun H, LinFu S, LiuLiang R, LvXiao, SongTu R, WeiQiang, XueWen B, YanShi B, YangLu, YuanHai C, ZengHao

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study compared different treatments for high-risk prostate cancer (PCa) and found that surgery (radical prostatectomy) or radiation therapy combined with hormone therapy provided the best overall survival rates, while hormone therapy alone or watchful waiting had the poorest outcomes. Surgery had a significantly better overall survival rate compared to radiation or brachytherapy, and also a lower risk of death from prostate cancer compared to radiation therapy. Adding hormone therapy to surgery improved survival, while adding it to radiation therapy did not surpass surgery but could improve outcomes for radiation therapy. The study recommends surgery or radiation therapy combined with hormone therapy as potential first-line treatments for high-risk prostate cancer, but emphasizes that individual patient preferences and tumor characteristics should also be considered.
Paper Details　
Original Abstract of the Article :
Prostate cancer (PCa) is the most common non-dermatologic cancer in the western countries in western countries. High-risk PCa accounts for 15% of the diagnosed cases. In this study, we compare the long-term survival outcomes of radical prostatectomy (RP), radiation therapy (RT), brachytherapy (BT), ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378991/

データ提供：米国国立医学図書館（NLM）

High-Risk Prostate Cancer: Choosing the Right Path in the Desert

This research investigates the survival outcomes of various treatment options for high-risk prostate cancer (PCa). The authors conducted a systematic review and meta-analysis comparing radical prostatectomy (RP), radiation therapy (RT), brachytherapy (BT), androgen-deprivation therapy (ADT), and watchful waiting (WW). Their findings suggest that RP and RT combined with ADT offer the best survival outcomes for patients with high-risk PCa. ADT alone or watchful waiting were associated with the worst outcomes. The study highlights the superiority of RP over RT or BT in terms of overall survival and cancer-specific mortality.

Radical Prostatectomy: A Leading Path in the Desert of High-Risk Prostate Cancer

This research indicates that radical prostatectomy (RP) and radiation therapy (RT) combined with androgen-deprivation therapy (ADT) offer the best survival outcomes for patients with high-risk prostate cancer. The study found that RP had a significantly better overall survival than RT or BT. Additionally, RP had a significantly lower cancer-specific mortality than RT. These findings highlight the potential of RP as a preferred treatment option for high-risk PCa.

Navigating the Desert of Prostate Cancer Treatment

This study sheds light on the various treatment options for high-risk prostate cancer, emphasizing the importance of tailoring treatment to individual patient needs. While RP and RT combined with ADT offer promising survival outcomes, other options like BT, ADT alone, and watchful waiting may be appropriate in specific cases. The authors highlight the need for a comprehensive evaluation, considering factors like tumor characteristics and patient preferences, to make informed decisions about the best treatment path.

Dr.Camel's Conclusion

This study provides valuable insights into the complex landscape of high-risk prostate cancer treatment. Like navigating a vast desert, it is essential to choose the right path based on individual needs and the available evidence. This study offers guidance for clinicians and patients alike, illuminating the potential benefits and limitations of different treatment options.
Date :
  1. Date Completed 2015-10-20
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25578739

DOI: Digital Object Identifier

PMC5378991

Related Literature

Article Analysis
・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.