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Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.
Author: AlbonicoMarco, AliSaid M, AllesRainer, AmeShaali M, BogochIsaac I, HattendorfJan, HuwylerJörg, KeiserJennifer, SpeichBenjamin, UtzingerJürg
Original Abstract of the Article :
Existing anthelmintic drugs (eg, albendazole and mebendazole) have low efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is exhausted. We aimed to investigate the strategy of combination chemotherapy with existing drugs to establish whether their efficacy cou...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/S1473-3099(14)71050-3
データ提供:米国国立医学図書館(NLM)
Combination Chemotherapy for Trichuris trichiura Infections: A Promising Approach
Trichuris trichiura infection, a common intestinal parasitic infection, can be challenging to treat with existing anthelmintic drugs. This randomized controlled trial investigates the efficacy of combination chemotherapy using albendazole, ivermectin, mebendazole, and oxantel pamoate against Trichuris trichiura and other soil-transmitted helminth infections.
Combination Therapy Shows Promise in Treating Trichuris trichiura
The study found that combination therapy with albendazole plus ivermectin or albendazole plus mebendazole was more effective than mebendazole alone in treating Trichuris trichiura infections. This suggests that combination therapy could be a valuable strategy for improving treatment outcomes for this parasitic infection.
Navigating the Desert of Parasitic Infections
This research emphasizes the need for innovative approaches to treating parasitic infections. Combination therapy, with its enhanced efficacy, could offer a significant improvement over existing treatments. Like a camel traversing a vast and challenging desert, researchers must be resourceful and adaptable in developing effective solutions for these persistent health problems.
Dr.Camel's Conclusion
The desert of parasitic infections is vast and often difficult to conquer. This study offers a promising new approach using combination therapy, reminding us that the search for better treatments requires creativity and a willingness to explore new possibilities.
Date :
- Date Completed 2015-05-04
- Date Revised 2015-03-09
Further Info :
Related Literature
English
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