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Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats.

Author: AokiT, FushikiH, HondaS, IrieM, IwashitaA, MuraiN, MurakamiY, NagakuraY, TamuraS

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The study investigated the relationship between serotonin transporter (SERT) occupancy and the analgesic effects of AS1069562 and duloxetine, both serotonin and norepinephrine reuptake inhibitors (SNRIs), in reserpine-induced myalgia (RIM) rats, an animal model of fibromyalgia. AS1069562 and duloxetine showed analgesic effects on muscular pain, with SERT occupancy levels above 70% being crucial for their effectiveness. These findings suggest that SERT occupancy levels are a valuable tool for determining appropriate analgesic doses of these drugs for treating pain in fibromyalgia patients.
Paper Details　
Original Abstract of the Article :
Serotonin (5-HT) and norepinephrine (NE) have been implicated in the mediation of endogenous analgesic mechanisms via the descending inhibitory pain pathway in the brain, and dysfunction in both the 5-HT and NE systems has been suggested as an etiology of fibromyalgia (FM). Given that 5-HT reuptake ...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuroscience.2014.12.065

データ提供：米国国立医学図書館（NLM）

Serotonin and Pain: A Complex Interplay in the Desert of Fibromyalgia

Fibromyalgia, a chronic pain disorder, can significantly impact a patient's quality of life. This study investigates the relationship between serotonin transporter (SERT) occupancy and analgesic effects of AS1069562 and duloxetine, two drugs that inhibit the reuptake of serotonin and norepinephrine. The researchers used a rat model of fibromyalgia-like pain and found that both drugs attenuated muscular hyperalgesia. They also discovered a strong correlation between SERT occupancy levels and analgesic effects, suggesting that targeting SERT may be a promising strategy for managing fibromyalgia pain.

SERT Occupancy: A Key to Unlock Pain Relief in Fibromyalgia

This study sheds light on the potential role of SERT occupancy in mediating the analgesic effects of AS1069562 and duloxetine in fibromyalgia. The findings suggest that targeting SERT may be a promising approach for managing fibromyalgia pain. However, further research is needed to confirm these findings and optimize the use of these drugs for pain management in fibromyalgia patients.

Fibromyalgia: A Persistent Desert of Pain

Fibromyalgia, like a relentless desert wind, can bring a constant barrage of pain. This study provides a glimmer of hope in the search for effective treatments, highlighting the potential role of SERT occupancy in managing fibromyalgia pain. It's essential to consult with a medical professional for personalized advice and treatment options, as the path to pain relief can be a long and challenging one.

Dr.Camel's Conclusion

This study offers a promising avenue for exploring new approaches to pain management in fibromyalgia. The findings suggest that targeting SERT may be a valuable strategy for alleviating fibromyalgia pain. However, like a mirage in the desert, the findings require further exploration to confirm their reliability and ensure their effectiveness in various populations.

Date :
  1. Date Completed 2015-12-01
  2. Date Revised 2015-02-27
Further Info :

Pubmed ID

25595980

DOI: Digital Object Identifier

10.1016/j.neuroscience.2014.12.065

Related Literature

Article Analysis
・Effects of reserpine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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