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Effectiveness of combined therapy with pirfenidone and inhaled N-acetylcysteine for advanced idiopathic pulmonary fibrosis: a case-control study.

Author: HommaSakae, IshidaFumiaki, IsobeKazutoshi, KikuchiNaoshi, MuramatsuYoko, SakamotoSusumu, SanoGo, SatohKeita, SuginoKeishi, TakaiYujiro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the effects of combination therapy with inhaled NAC and pirfenidone in patients with advanced IPF.
Paper Details　
Original Abstract of the Article :
Treatment with pirfenidone may slow the decline in vital capacity and increase progression-free survival (PFS) in idiopathic pulmonary fibrosis (IPF). The effects of combination therapy with inhaled N-acetylcysteine (NAC) and pirfenidone are unclear. We assessed the effects of this combination thera...See full text at original site
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引用元：
https://doi.org/10.1111/resp.12477

データ提供：米国国立医学図書館（NLM）

Investigating the Effectiveness of Combined Therapy for Advanced Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease with limited treatment options. This research examines the potential benefits of combining pirfenidone with inhaled N-acetylcysteine (NAC) for treating advanced IPF. The researchers conducted a case-control study to compare the outcomes of patients receiving this combination therapy with those receiving pirfenidone alone. Their findings shed light on the effectiveness of this therapeutic approach.

Combined Therapy Shows Promise in Treating IPF

The researchers found that the combination therapy of pirfenidone and inhaled NAC may be more effective than pirfenidone alone in slowing the decline in vital capacity and improving progression-free survival in patients with advanced IPF. This exciting discovery suggests that combining therapies could offer a more effective approach to managing this complex disease.

Combating IPF - A Multifaceted Approach

This research highlights the importance of exploring multiple therapeutic strategies to combat IPF effectively. The findings suggest that combining medications with different mechanisms of action may offer a more comprehensive approach to managing this disease and improving patient outcomes.

Dr.Camel's Conclusion

This study underscores the importance of exploring innovative treatment strategies for IPF, a challenging disease with a significant impact on patients' lives. Combining different therapies may offer a more effective approach to managing this disease and improving outcomes.

Date :
  1. Date Completed 2016-02-11
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25639750

DOI: Digital Object Identifier

10.1111/resp.12477

Related Literature

Article Analysis
・Effects of acetylcysteine oral inhalation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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