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Long-term statin treatment in children with familial hypercholesterolemia: more insight into tolerability and adherence.

Author: AvisHans J, BraamskampMarjet J A M, HuttenBarbara A, KasteleinJohn J P, KustersD Meeike, SmetsEllen M A, WiegmanAlbert, WijburgFrits A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Statin therapy was well tolerated in young adults with familial hypercholesterolemia (FH) who started statin therapy in childhood. Only 1.5% of patients discontinued therapy due to side effects, which were mainly muscle complaints and gastrointestinal symptoms. Adherence to statin therapy was good, with 82.4% of patients remaining on treatment and 78.7% being adherent after 10 years of treatment.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Statins are currently the preferred pharmacological therapy in individuals with familial hypercholesterolemia (FH) with the aim to prevent premature atherosclerosis. In adults, these agents have been proven to be safe and well tolerated; however, non-adherence is a significant clinical i...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372689/

データ提供：米国国立医学図書館（NLM）

Long-Term Statin Therapy: Assessing Tolerability and Adherence in Familial Hypercholesterolemia

The field of [cardiology] is dedicated to preventing and treating [heart disease]. This research focuses on the long-term use of [statin therapy] in individuals with [familial hypercholesterolemia (FH)], a genetic condition characterized by high cholesterol levels. The study aimed to evaluate the tolerability and adherence to statin therapy in young adult FH patients who had initiated treatment in childhood.

Statin Therapy: Demonstrating Long-Term Safety and Good Adherence

The study found that [statin therapy] was well-tolerated and resulted in good adherence rates in young adult FH patients who had initiated treatment in childhood. The majority of patients remained on statin therapy for at least 10 years, with a minimal number discontinuing due to side effects. The findings highlight the potential for long-term benefits of statin therapy in reducing cardiovascular risks associated with FH.

Managing Cholesterol: A Lifelong Commitment

This research underscores the importance of maintaining a lifelong commitment to managing cholesterol levels, particularly in individuals with FH. The study's findings support the use of statin therapy as a safe and effective long-term treatment option for reducing cardiovascular risks. It's essential to consult with your healthcare provider to discuss your individual risk factors, treatment options, and any concerns you may have about statin therapy.

Dr.Camel's Conclusion

This study is like a camel traversing a vast desert, where statin therapy acts as a reliable guide to help navigate the journey of managing cholesterol levels. The research confirms the long-term safety and good adherence to statin therapy in FH patients, highlighting its potential for reducing cardiovascular risks and improving long-term health outcomes.

Date :
  1. Date Completed 2015-08-11
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25644328

DOI: Digital Object Identifier

PMC4372689

SNS
PICO Info
in preparation
Languages

English

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