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[Effectiveness and safety of losartan and its combination with amlodipine in therapy of arterial hypertension].

Author: BazaevaE V, BoitsovS A, DrapkinaO M, Luk'ianovM M, PanovA V, ShchukinaG N, Terent'evB P, TiurinV P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Losartan and amlodipine are effective and safe agents for AH therapy. The target AP value was reached in 73% of the cases after stage 1 and in 95% cases after stage 2. The safety profiles of both drugs were on the whole positive.
Paper Details　
Original Abstract of the Article :
AIM: To estimate effectiveness and safety of losartan and its combination with amlodipine in therapy of arterial hypertension. MATERIALS AND METHODS: The study based at 6 clinical centres was conducted in two stages. All 160 patients with grade I-II AH (103 women and 57 men aged 54 ± 12 yr) partici...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/25702431

データ提供：米国国立医学図書館（NLM）

Treating High Blood Pressure: Losartan and Amlodipine

High blood pressure, a silent killer, is a major risk factor for cardiovascular disease. This study evaluates the effectiveness and safety of losartan, a medication commonly used to lower blood pressure, and its combination with amlodipine, another antihypertensive medication. The study aims to assess the efficacy and safety of these medications in treating grade I-II arterial hypertension.

A Two-Pronged Approach: Losartan and Amlodipine

The study involved two stages: losartan alone for 8 weeks, followed by a combination therapy with amlodipine if the desired blood pressure level was not achieved. The researchers observed a significant decrease in blood pressure with losartan alone, and further improvement was observed with the combination therapy.

Managing High Blood Pressure: A Safe and Effective Approach

The study found that both losartan and its combination with amlodipine were effective and safe in treating grade I-II arterial hypertension. These medications provide valuable tools for managing blood pressure and reducing the risk of cardiovascular complications.

Dr.Camel's Conclusion

This study confirms the effectiveness and safety of losartan and its combination with amlodipine in treating high blood pressure. These medications offer valuable tools for managing blood pressure and improving patient outcomes.

Date :
  1. Date Completed 2015-03-10
  2. Date Revised 2015-02-23
Further Info :

Pubmed ID

25702431

DOI: Digital Object Identifier

25702431

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Languages

Russian

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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