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Transverse relaxation dispersion of the p7 membrane channel from hepatitis C virus reveals conformational breathing.

Author: BrüschweilerSven, ChouJames J, DevJyoti, OuyangBo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study determined the conformational dynamics and solvent accessibility of the p7 channel. The proton exchange measurements showed that the cavity-lining residues are largely water accessible. Relaxation dispersion data showed that residues Val7 and Leu8 are subject to large chemical exchange. The hinge regions connecting the narrow and wide regions of the funnel show strong relaxation dispersion and are the binding sites for rimantadine. Rimantadine decreased the conformational dynamics near the asparagine ring and the hinge area. These results support the molecular wedge mechanism of rimantadine inhibition of the HCV p7 channel.
Paper Details　
Original Abstract of the Article :
The p7 membrane protein encoded by hepatitis C virus (HCV) assembles into a homo-hexamer that selectively conducts cations. An earlier solution NMR structure of the hexameric complex revealed a funnel-like architecture and suggests that a ring of conserved asparagines near the narrow end of the funn...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/25724842

データ提供：米国国立医学図書館（NLM）

Exploring the Dynamics of the p7 Membrane Channel: A Molecular Dance

The hepatitis C virus (HCV) is a formidable foe, and understanding its mechanisms is crucial for developing effective treatments. This research delves into the dynamics of the p7 membrane channel, a key component of the HCV, using advanced techniques like NMR spectroscopy. The study aims to unravel the intricate movements of this channel, much like a skilled dancer navigating a complex choreography.

A Dance of Molecules: Unveiling the Dynamics of the p7 Channel

This research provides valuable insights into the dynamics of the p7 membrane channel. The researchers used NMR spectroscopy to study the conformational changes and solvent accessibility of the channel. The findings suggest that the channel undergoes significant conformational breathing, which is essential for its function.

Navigating the Desert of Viral Infections: Understanding HCV

This research is a step forward in our understanding of HCV. By unraveling the dynamics of the p7 channel, researchers are gaining valuable insights into the virus's mechanisms, paving the way for the development of more effective treatments.

Dr. Camel's Conclusion

This research is a captivating dance through the desert of viral infection. By studying the dynamics of the p7 channel, researchers are gaining a deeper understanding of HCV, a journey that could lead to new and innovative treatments. This research is a testament to the power of scientific exploration in conquering the challenges posed by viral infections.

Date :
  1. Date Completed 2016-02-02
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

25724842

DOI: Digital Object Identifier

NIHMS668346

Related Literature

Article Analysis
・Effects of rimantadine
SNS
PICO Info
in preparation
Languages

English

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