Randomised clinical trial: deep remission in biologic and immunomodulator naïve patients with Crohn's disease - a SONIC post hoc analysis.

Author: BevelanderG S, ColombelJ-F, CornillieF J, KornbluthA, MantzarisG J, OortwijnA, ReinischW, RutgeertsP, SandbornW J, TangK L

Paper Details 
Original Abstract of the Article :
BACKGROUND: As treatment goals in Crohn's disease (CD) evolve, targets now include clinical remission (CR), mucosal healing (MH) and biological remission [C-reactive protein normalisation (CRPnorm )]. AIMS: To evaluate the association of baseline factors and treatment with the achievement of differ...See full text at original site
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引用元:
https://doi.org/10.1111/apt.13139

データ提供:米国国立医学図書館(NLM)

Deep Remission in Crohn's Disease: A Camel's Oasis in the Desert of Inflammation

Crohn's disease, like a relentless desert wind, can cause chronic inflammation in the digestive tract. This research explores different remission strategies for Crohn's disease, aiming to achieve not only clinical remission but also mucosal healing, a state where the lining of the gut is restored to its healthy state. The authors analyzed data from a clinical trial, SONIC, examining the effectiveness of different treatment combinations, including infliximab and azathioprine, in achieving deep remission, a combination of clinical remission and mucosal healing. Their findings suggest that combination therapy is more effective than monotherapy in achieving this goal, leading to improved outcomes for patients with Crohn's disease.

A Camel's Oasis in the Desert of Inflammation: Combination Therapy for Deep Remission

The research highlights the effectiveness of combination therapy, such as infliximab and azathioprine, in achieving deep remission in Crohn's disease patients. This finding suggests that a multi-pronged approach can be more effective in managing the disease and improving long-term outcomes.

A Camel's Oasis in the Desert of Inflammation: Living Well With Crohn's Disease

While there is no cure for Crohn's disease, this research offers hope for achieving long-term remission and improving quality of life. It's important to work closely with a healthcare professional to develop a personalized treatment plan that addresses individual needs and goals. Following a healthy diet, managing stress, and engaging in regular exercise can also contribute to overall well-being and disease management.

Dr.Camel's Conclusion

This research provides valuable insights into the effectiveness of different treatment strategies for Crohn's disease, demonstrating the potential of combination therapy to achieve deep remission, a combination of clinical remission and mucosal healing. The study emphasizes the importance of personalized treatment plans and collaborative care between patients and healthcare professionals to optimize long-term outcomes and improve quality of life for those living with Crohn's disease.

Date :
  1. Date Completed 2015-07-08
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

25728587

DOI: Digital Object Identifier

10.1111/apt.13139

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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