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Randomised clinical trial: deep remission in biologic and immunomodulator naïve patients with Crohn's disease - a SONIC post hoc analysis.
Author: BevelanderG S, ColombelJ-F, CornillieF J, KornbluthA, MantzarisG J, OortwijnA, ReinischW, RutgeertsP, SandbornW J, TangK L
Original Abstract of the Article :
BACKGROUND: As treatment goals in Crohn's disease (CD) evolve, targets now include clinical remission (CR), mucosal healing (MH) and biological remission [C-reactive protein normalisation (CRPnorm )]. AIMS: To evaluate the association of baseline factors and treatment with the achievement of differ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1111/apt.13139
データ提供:米国国立医学図書館(NLM)
Deep Remission in Crohn's Disease: A Camel's Oasis in the Desert of Inflammation
Crohn's disease, like a relentless desert wind, can cause chronic inflammation in the digestive tract. This research explores different remission strategies for Crohn's disease, aiming to achieve not only clinical remission but also mucosal healing, a state where the lining of the gut is restored to its healthy state. The authors analyzed data from a clinical trial, SONIC, examining the effectiveness of different treatment combinations, including infliximab and azathioprine, in achieving deep remission, a combination of clinical remission and mucosal healing. Their findings suggest that combination therapy is more effective than monotherapy in achieving this goal, leading to improved outcomes for patients with Crohn's disease.
A Camel's Oasis in the Desert of Inflammation: Combination Therapy for Deep Remission
The research highlights the effectiveness of combination therapy, such as infliximab and azathioprine, in achieving deep remission in Crohn's disease patients. This finding suggests that a multi-pronged approach can be more effective in managing the disease and improving long-term outcomes.
A Camel's Oasis in the Desert of Inflammation: Living Well With Crohn's Disease
While there is no cure for Crohn's disease, this research offers hope for achieving long-term remission and improving quality of life. It's important to work closely with a healthcare professional to develop a personalized treatment plan that addresses individual needs and goals. Following a healthy diet, managing stress, and engaging in regular exercise can also contribute to overall well-being and disease management.
Dr.Camel's Conclusion
This research provides valuable insights into the effectiveness of different treatment strategies for Crohn's disease, demonstrating the potential of combination therapy to achieve deep remission, a combination of clinical remission and mucosal healing. The study emphasizes the importance of personalized treatment plans and collaborative care between patients and healthcare professionals to optimize long-term outcomes and improve quality of life for those living with Crohn's disease.
Date :
- Date Completed 2015-07-08
- Date Revised 2022-04-09
Further Info :
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