Molecular pharmacology of antihistamines in inhibition of oxidative burst of professional phagocytes.

Author: DrábikováKatarína, JančinováViera, NosáľRadomír, PerečkoTomáš

Paper Details 
Original Abstract of the Article :
Antihistamines of the H₁and H₃/H₄groups interfere with oxidative burst of human professional phagocytes in vitro. In the concentration of 10 μM, H₁antihistamines of the 1st and 2nd generation inhibited oxidative burst of human neutrophils in the rank order of potency: dithiaden > loratadine > bromph...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.4149/gpb_2014040

データ提供:米国国立医学図書館(NLM)

Antihistamines: A New Perspective on Their Actions

The field of pharmacology is constantly exploring the multifaceted nature of drugs, uncovering new mechanisms of action and potential therapeutic applications. This research investigates the effects of antihistamines on the oxidative burst of professional phagocytes, cells involved in the immune response. It's like exploring a hidden oasis in the vast desert of pharmacology, unveiling new insights into the workings of these common medications.

Antihistamines: Beyond Allergy Relief

The study reveals that antihistamines, traditionally known for their ability to block histamine receptors, can also modulate the activity of professional phagocytes, affecting their ability to generate reactive oxygen species. It's like discovering a new species of plant in the desert, possessing unexpected properties that could be beneficial for health. The study suggests that H1 antihistamines are more potent than H3/H4 antihistamines in inhibiting oxidative burst in professional phagocytes. It's like comparing two types of cacti—one with more potent medicinal properties than the other—highlighting the importance of understanding the nuances of drug actions.

A New Avenue for Therapeutic Applications

The findings of this research could lead to new therapeutic applications for antihistamines, potentially extending their benefits beyond allergy relief. It's like finding a new route through the desert, leading to a wider range of potential uses for these familiar medications.

Dr.Camel's Conclusion

This research sheds light on the multifaceted nature of antihistamines, revealing their potential to influence immune responses beyond allergy relief. It's like uncovering a hidden oasis in the desert of pharmacology, promising new therapeutic avenues for these common medications.

Date :
  1. Date Completed 2015-06-18
  2. Date Revised 2015-05-15
Further Info :

Pubmed ID

25730898

DOI: Digital Object Identifier

10.4149/gpb_2014040

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.