The Rise and Fall of Oral Ketoconazole.

Author: GuptaAditya K, LyonsDanika C A

Paper Details 
Original Abstract of the Article :
Ketoconazole was the first broad-spectrum oral antifungal agent available to treat systemic and superficial mycoses. Evidence of hepatotoxicity associated with its use emerged within the first few years of its approval. Growing evidence of serious side effects including endocrine dysregulation, seve...See full text at original site
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引用元:
https://doi.org/10.1177/1203475415574970

データ提供:米国国立医学図書館(NLM)

The Rise and Fall of Oral Ketoconazole: A Tale of Two Deserts

The world of medicine is a vast and ever-changing landscape. Drugs, like desert oases, can appear promising at first, but sometimes their true nature is revealed over time. This article delves into the history of oral ketoconazole, a drug once hailed as a beacon of hope for fungal infections, but later found to have significant side effects.

The Shifting Sands of Medical Knowledge: A Cautionary Tale

The discovery of ketoconazole was a triumph, like discovering a lush oasis in a barren desert. However, as time passed, concerns emerged about its safety, particularly regarding its potential for hepatotoxicity and endocrine disruption. The initial promise faded like a mirage, leaving behind a cautionary tale about the importance of ongoing research and monitoring in the realm of medicine.

Navigating the Medical Landscape: The Camel's Perspective

This article reminds us that even the most promising treatments can have hidden dangers. It underscores the importance of vigilance and a constant quest for safer and more effective therapies. It's a reminder that the medical landscape, like a desert, can be treacherous, but with careful navigation, we can find our way to safer shores.

Dr. Camel's Conclusion

This account of ketoconazole's rise and fall is a reminder that the medical world is a dynamic landscape, constantly evolving as our understanding of disease and treatment progresses. It's a journey of discovery, where we must be prepared to adapt and evolve alongside the sands of time.

Date :
  1. Date Completed 2015-10-01
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

25775613

DOI: Digital Object Identifier

10.1177/1203475415574970

Related Literature

SNS
PICO Info
in preparation
Languages

English

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