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Ceftriaxone-resistant Salmonella enterica serotype typhimurium sequence type 313 from Kenyan patients is associated with the blaCTX-M-15 gene on a novel IncHI2 plasmid.

Author: DouganGordon, KariukiSamuel, KiiruJohn, KingsleyRobert A, LangridgeGemma, NjorogeSamuel, OkoroChinyere, OmuseGeoffrey, RevathiGunturu

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study characterized nine multidrug-resistant Salmonella Typhimurium isolates from an outbreak in Kenya. The isolates were resistant to multiple antibiotics, including ceftriaxone, due to the presence of several resistance genes. The findings highlight the emergence of a new, ceftriaxone-resistant clone of S. Typhimurium ST313, posing a significant challenge for managing invasive NTS in sub-Saharan Africa.
Paper Details　
Original Abstract of the Article :
Multidrug-resistant bacteria pose a major challenge to the clinical management of infections in resource-poor settings. Although nontyphoidal Salmonella (NTS) bacteria cause predominantly enteric self-limiting illness in developed countries, NTS is responsible for a huge burden of life-threatening b...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432211/

データ提供：米国国立医学図書館（NLM）

Ceftriaxone-Resistant Salmonella: A Threat in Kenya

We're exploring the alarming rise of antibiotic resistance, a global health challenge, and its impact on a specific strain of bacteria, *Salmonella enterica* serotype Typhimurium, in Kenya. This research focuses on a particularly concerning strain, ST313, known for causing severe infections, particularly in sub-Saharan Africa. The study meticulously characterized nine isolates of this strain, all of which were resistant to ceftriaxone, a crucial antibiotic often used to treat bacterial infections. This resistance poses a significant challenge to clinical management, as it limits treatment options.

The researchers used a combination of genetic analysis and microbiological techniques to understand the mechanisms behind the resistance. They discovered that the resistance to ceftriaxone was linked to the presence of the blaCTX-M-15 gene. This gene, found on a novel plasmid called pKST313, allows the bacteria to effectively disarm ceftriaxone.

Ceftriaxone-Resistant Salmonella: A Call for Action

The emergence of this ceftriaxone-resistant strain could have a profound impact on the effectiveness of treating severe infections in sub-Saharan Africa, highlighting the need for vigilant surveillance and the development of new treatment strategies to combat antibiotic resistance.

Ceftriaxone-Resistant Salmonella: A Global Challenge

This study serves as a stark reminder that antibiotic resistance is a global health threat, requiring urgent action to prevent the emergence of untreatable infections. It's a race against time to protect our health and prevent the collapse of our modern medical system.

Dr.Camel's Conclusion

This research emphasizes the urgent need to address antibiotic resistance, a silent threat lurking in our world. It's time to invest in research and development of new antibiotics and implement strategies to prevent the spread of resistant bacteria. The future of healthcare, my friend, depends on it.

Date :
  1. Date Completed 2016-02-12
  2. Date Revised 2023-07-10
Further Info :

Pubmed ID

25779570

DOI: Digital Object Identifier

PMC4432211

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Languages

English

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