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Structural and functional neuroimaging findings associated with the use of clozapine in schizophrenia: a systematic review.

Author: ChagasMarcos H, CrippaJosé A, GarciaGiovana J, HallakJaime E, Machado-de-SousaJoão P, SilvaCarlos H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study reviewed the available literature on the structural and functional neuroimaging findings associated with use of clozapine.
Paper Details　
Original Abstract of the Article :
Schizophrenia is one of the most severe psychiatric disorders, and its current treatment relies on antipsychotic medications with only partial effectiveness. Clozapine is an atypical antipsychotic with a specific profile of action indicated for treatment-resistant schizophrenia. Neuroimaging studies...See full text at original site
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引用元：
https://doi.org/10.1590/1516-4446-2014-1387

データ提供：米国国立医学図書館（NLM）

Clozapine and Schizophrenia: A Journey Through the Brain Desert

This research embarks on a fascinating journey through the [neurological] desert, exploring the effects of clozapine, an atypical antipsychotic, on the brains of individuals with schizophrenia. Schizophrenia, like a desert mirage, can distort reality, leaving individuals lost and disoriented. Clozapine, like a skilled desert guide, offers a lifeline for those struggling with this complex condition.

Exploring the Neurological Landscape: The Impact of Clozapine

This study reviews the available neuroimaging studies on clozapine's effects on the brain. The authors highlight the potential benefits of clozapine for individuals with treatment-resistant schizophrenia. Neuroimaging techniques, like a camel caravan's keen observation of the desert landscape, offer insights into how clozapine interacts with the brain. The study suggests that clozapine may have a unique profile of action, potentially influencing the brain's neural pathways and promoting recovery.

Understanding the Brain: A Quest for New Therapies

This study underscores the importance of understanding the neurological underpinnings of schizophrenia and the potential of clozapine to address this complex disorder. By delving into the brain's desert landscape, researchers can better understand the mechanisms of action of antipsychotic medications and develop more effective therapies for individuals with schizophrenia. The authors advocate for further research into the neurological effects of clozapine, seeking to unravel the mysteries of this challenging condition and unlock new treatment possibilities.

Dr.Camel's Conclusion

This research sheds light on the potential of clozapine to navigate the complex landscape of schizophrenia. While more research is needed to fully understand its mechanisms of action, this study offers hope for those struggling with treatment-resistant schizophrenia. The journey into the brain desert continues, with researchers seeking to uncover new therapies and provide relief for those impacted by this debilitating condition.
Date :
  1. Date Completed 2015-09-22
  2. Date Revised 2018-12-18
Further Info :

Pubmed ID

25806554

DOI: Digital Object Identifier

10.1590/1516-4446-2014-1387

SNS
PICO Info
in preparation
Languages

English

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