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A Risk-Benefit Assessment of Dementia Medications: Systematic Review of the Evidence.

Author: BuckleyJacob S, SalpeterShelley R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Cholinesterase inhibitors (ChEIs) produce small, short-lived improvements in cognitive function in mild to moderate dementia, with marginal benefits seen with severe disease, long-term treatment, and advanced age. Memantine monotherapy may have minimal benefits in moderate to severe dementia, balanced by minimal adverse effects.
Paper Details　
Original Abstract of the Article :
BACKGROUND: There is no cure for dementia, and no treatments exist to halt or reverse the course of the disease. Treatments are aimed at improving cognitive and functional outcomes. OBJECTIVE: Our objective was to review the basis of pharmacological treatments for dementia and to summarize the bene...See full text at original site
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引用元：
https://doi.org/10.1007/s40266-015-0266-9

データ提供：米国国立医学図書館（NLM）

A Risk-Benefit Assessment of Dementia Medications: Systematic Review of the Evidence

The treatment of [dementia] is a complex and challenging undertaking. This study conducts a [systematic review] of the evidence on the benefits and risks of available medications for dementia. It aims to provide a comprehensive assessment of the efficacy and safety of these treatments, guiding clinicians in their decision-making and helping patients and families make informed choices. This research is a valuable resource for navigating the complexities of dementia care, offering insights into the current state of treatment options.

Weighing the Benefits and Risks: A Critical Review of Dementia Medications

The study reveals that while cholinesterase inhibitors (ChEIs) and memantine may offer modest cognitive benefits for some patients with dementia, these benefits are often small and short-lived. Moreover, both medications are associated with significant side effects, particularly in older patients. The study underscores the importance of carefully weighing the potential benefits and risks of these medications, considering individual patient characteristics and the severity of their condition. This research emphasizes the ongoing need for new and more effective treatments for dementia.

Navigating the Uncertainties of Dementia: Seeking New Treatment Options

This study highlights the ongoing need for research into new and more effective treatments for dementia. While current medications may offer some benefits, the overall impact on patients' lives is often limited, and the risks of side effects can be significant. The study underscores the importance of seeking new treatment options that can provide more substantial benefits with fewer adverse effects. This research is a reminder that the quest for better dementia treatments continues.

Dr.Camel's Conclusion

This study is like a journey through a desert of uncertainties surrounding dementia treatment. It reveals the limitations of current medications and emphasizes the need for continued research. The study underscores the importance of careful patient selection and monitoring when considering these treatments and the ongoing need for new and more effective therapies that can improve the lives of those affected by dementia.

Date :
  1. Date Completed 2015-12-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25941104

DOI: Digital Object Identifier

10.1007/s40266-015-0266-9

Related Literature

Article Analysis
・Effective treatment of dementia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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