Effect of sulfonylureas administered centrally on the blood glucose level in immobilization stress model.

Author: HongJae-Seung, JungJun-Sub, KimSung-Su, LimSu-Min, ParkSoo-Hyun, SharmaNaveen, SimYun-Beom, SuhHong-Won

Paper Details 
Original Abstract of the Article :
Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice were once enforced into immobilization stress for 30 min and returned to the cage. T...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422958/

データ提供:米国国立医学図書館(NLM)

Sulfonylureas: A New Twist in the Desert of Diabetes

Sulfonylureas are a common class of medications used to treat type 2 diabetes. This study explores the effects of sulfonylureas when administered centrally in mice. It's like discovering a hidden spring in the desert, revealing a new perspective on how these drugs work.

Unlocking the Potential of Sulfonylureas

The researchers found that administering sulfonylureas directly into the brain of mice during immobilization stress had a significant effect on blood glucose levels. This suggests that sulfonylureas may have additional mechanisms of action beyond their well-known role in stimulating insulin release from the pancreas. It's like finding a new oasis in the desert – a source of hope for better diabetes management.

Implications for Diabetes Management

This research opens new doors for understanding the potential of sulfonylureas in diabetes management. It suggests that targeting the brain may be a promising approach to improving blood glucose control. It's like finding a new path through the desert, leading to more effective ways to manage this complex condition.

Dr.Camel's Conclusion

This research, like a camel caravan exploring new routes, delves into the hidden potential of sulfonylureas in diabetes management. The findings suggest that these drugs may have a wider range of effects, offering exciting possibilities for future research and development in diabetes treatment.

Date :
  1. Date Completed 2015-05-08
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

25954123

DOI: Digital Object Identifier

PMC4422958

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Languages

English

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