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Impact of Intravenous Lysine Acetylsalicylate Versus Oral Aspirin on Prasugrel-Inhibited Platelets: Results of a Prospective, Randomized, Crossover Study (the ECCLIPSE Trial).

Author: BernardoEsther, FernándezCristina, Fernández-OrtizAntonio, MacayaCarlos, MartínAgustín, Núñez-GilIván, Ortega-PozziMaría Aranzazu, TiradoGabriela, VilacostaIsidre, VivasDavid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prasugrel and ticagrelor are new P2Y12-adenosine diphosphate receptor antagonists that are more effective than clopidogrel in reducing cardiovascular events in patients with an acute coronary syndrome. This study investigated the effects of achieving faster and stronger cyclooxygenase inhibition with intravenous lysine acetylsalicylate (LA) compared with oral aspirin on prasugrel-inhibited platelets.
Paper Details　
Original Abstract of the Article :
Prasugrel and ticagrelor, new P2Y12-adenosine diphosphate receptor antagonists, are associated with greater pharmacodynamic inhibition and reduction of cardiovascular events compared with clopidogrel in patients with an acute coronary syndrome. However, evidence is lacking about the effects of achie...See full text at original site
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引用元：
https://doi.org/10.1161/CIRCINTERVENTIONS.114.002281

データ提供：米国国立医学図書館（NLM）

Intravenous Lysine Acetylsalicylate: A Faster Path to Platelet Inhibition?

The field of cardiovascular medicine is constantly evolving, seeking new ways to prevent blood clots and reduce the risk of heart attacks and strokes. This study delves into the effectiveness of intravenous lysine acetylsalicylate (LA) compared to oral aspirin in inhibiting platelet aggregation, particularly in patients taking prasugrel, a new antiplatelet drug. The researchers aimed to investigate whether achieving faster and stronger cyclooxygenase inhibition with LA could provide an advantage over oral aspirin.

LA's Role in Platelet Inhibition: A Shortcut Through the Desert of Cardiovascular Risk

The study aimed to compare the effects of intravenous LA and oral aspirin on prasugrel-inhibited platelets. While the study's results are inconclusive, it provides valuable insights into the potential of LA in achieving faster and stronger cyclooxygenase inhibition. The researchers highlight the need for further studies to definitively determine the optimal approach for platelet inhibition in patients taking prasugrel.

Navigating the Complexities of Cardiovascular Medicine

This research underscores the complexities of cardiovascular medicine, where even small changes in treatment strategies can have significant implications. It's like navigating a desert landscape, where every decision can impact the journey. The study's findings highlight the importance of carefully considering the pros and cons of different treatment options and seeking further research to ensure optimal patient care.

Dr.Camel's Conclusion

This study offers a glimpse into the potential of LA in achieving faster and stronger platelet inhibition, but more research is needed to solidify its role in cardiovascular medicine. It's like exploring a new oasis in the vast desert of antiplatelet therapies. We need to keep digging deeper to understand the full implications of this approach and ensure that patients receive the most effective treatment for their specific needs.

Date :
  1. Date Completed 2016-02-25
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

25957056

DOI: Digital Object Identifier

10.1161/CIRCINTERVENTIONS.114.002281

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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