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Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy.

Author: , AnanworanichJintanat, BennettKara, ChomcheyNitiya, DeGruttolaVictor, EbenezerGigi, GerschensonMariana, HauerPeter, HongchookiatPiranun, JadwattanakulTanate, MathajittiphunPornpen, McArthurJustin C, NakamotoBeau, PhanuphakNittaya, PhanuphakPraphan, PraihirunkitPairoa, ShikumaCecilia M, TeeratakulpisarnNipat

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This abstract examines the impact of initiating antiretroviral therapy (ART) on epidermal nerve fiber density (ENFD) in HIV-infected individuals. The study found that while there were individual variations in ENFD change over time, the changes were not consistently linked to the type of nucleoside medication used or the development of neuropathy. The findings suggest that ENFD may not be a reliable predictor of neuropathy risk in all HIV-infected populations.
Paper Details　
Original Abstract of the Article :
Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how it is altered when mitochondrial toxic nucleoside medications...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/26002840

データ提供：米国国立医学図書館（NLM）

Epidermal Nerve Fiber Density: A New Frontier in HIV-Associated Sensory Neuropathy

This study explores the role of distal leg epidermal nerve fiber density (ENFD) as a predictor of HIV sensory neuropathy (SN) risk. It's like a camel navigating a treacherous desert, relying on instinct and experience to avoid potential pitfalls. The researchers delved into the complex relationship between ENFD and HIV SN risk, examining how it changes with the initiation of antiretroviral therapy (ART). They also assessed the impact of mitochondrial toxic nucleoside medications on ENFD. The researchers conducted a randomized controlled trial in 150 Thai subjects, examining changes in ENFD over 72 weeks. The study found individual variations in ENFD changes, underscoring the complexity of HIV SN and the need for individualized approaches to management.

ENFD: A Complex Marker of HIV Sensory Neuropathy Risk

This study reveals the complex nature of ENFD as a predictor of HIV sensory neuropathy risk. It's like a shifting desert landscape, where the terrain can change unexpectedly, making navigation challenging. The researchers found that ENFD changes varied significantly among individuals, highlighting the need for careful monitoring and personalized treatment approaches.

Navigating the Shifting Sands of HIV Sensory Neuropathy

This research emphasizes the importance of ongoing monitoring and personalized treatment approaches for HIV sensory neuropathy. It's like navigating a desert with shifting dunes – vigilance and adaptability are key to ensuring safe passage. By carefully evaluating ENFD changes and tailoring treatment strategies to individual needs, we can better manage the risks associated with HIV sensory neuropathy.

Dr.Camel's Conclusion

This study provides valuable insights into the complex relationship between ENFD and HIV sensory neuropathy risk, highlighting the need for individualized approaches to management and ongoing monitoring of ENFD changes.

Date :
  1. Date Completed 2016-08-24
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26002840

DOI: Digital Object Identifier

NIHMS707504

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in preparation
Languages

English

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