Paper Details
- Home
- Paper Details
Oseltamivir produces hypothermic and neuromuscular effects by inhibition of nicotinic acetylcholine receptor functions: comparison to procaine and bupropion.
Author: ChazonoKaori, FukushimaAkihiro, HashimotoYuichi, IwajimaYui, MaedaYasuhiro, OhsawaMasahiro, OnoHideki, YamamotoShohei
Original Abstract of the Article :
Oseltamivir, an anti-influenza virus drug, induces marked hypothermia in normal mice. We have proposed that the hypothermic effect arises from inhibition of the nicotinic acetylcholine receptor function of sympathetic ganglion neurons which innervate the brown adipose tissue (a heat generator). It h...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/j.ejphar.2015.06.004
データ提供：米国国立医学図書館（NLM）
The Hypothermic and Neuromuscular Effects of Oseltamivir: A Comparison to Procaine and Bupropion
This study investigates the hypothermic and neuromuscular effects of oseltamivir, an anti-influenza virus drug, and compares its actions to those of procaine and bupropion. The authors propose that oseltamivir's hypothermic effect may result from inhibition of nicotinic acetylcholine receptor function. This study investigates the hypothermic and neuromuscular effects of oseltamivir, an anti-influenza virus drug, and compares its actions to those of procaine and bupropion, proposing that oseltamivir's hypothermic effect may result from inhibition of nicotinic acetylcholine receptor function.Oseltamivir's Effects on Nicotinic Acetylcholine Receptors
This study provides evidence that oseltamivir, like procaine and bupropion, can inhibit nicotinic acetylcholine receptor function. The authors suggest that this inhibition may contribute to oseltamivir's hypothermic effect and its potential neuromuscular effects. This study provides evidence that oseltamivir, like procaine and bupropion, can inhibit nicotinic acetylcholine receptors, suggesting that this inhibition may contribute to oseltamivir's hypothermic effect and its potential neuromuscular effects.Understanding the Potential Side Effects of Oseltamivir
This study highlights the importance of understanding the potential side effects of oseltamivir. The findings suggest that oseltamivir may have non-selective ion channel blocking effects, similar to local anesthetics.Dr.Camel's Conclusion
This study, like a camel caravan venturing into the desert of pharmacological effects, reveals the multifaceted actions of oseltamivir. The researchers discovered that oseltamivir, like a shifting sand dune, can influence nicotinic acetylcholine receptors, leading to hypothermic and neuromuscular effects. This study's findings, like a guidepost in the desert, underscore the need to carefully consider the potential side effects of this widely used antiviral drug.Date :
- Date Completed 2016-05-24
- Date Revised 2015-08-18
Further Info :
Related Literature
Article Analysis
SNS
PICO Info
in preparation
Languages
English
Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.