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Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients.

Author: CaylaGuillaume, ColletJean-Philippe, FinziJonathan, HulotJean-Sébastien, MontalescotGilles, SimonNicolas

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

CYP2C19*2 allele carriage and the use of omeprazole/esomeprazole were associated with inter-individual variability in the active metabolite clearance of clopidogrel. This highlights the importance of considering genetic factors and drug interactions when prescribing clopidogrel.
Paper Details　
Original Abstract of the Article :
PURPOSE: Proton-pump Inhibitors use and CYP2C19 loss-of-function alleles are associated with reduced responsiveness to standard clopidogrel doses and increased cardiovascular events. METHODS: Post-myocardial infarction patients heterozygous (wild type [wt]/*2, n = 41) or homozygous (*2/*2, n = 7) f...See full text at original site
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引用元：
https://doi.org/10.1007/s00228-015-1882-3

データ提供：米国国立医学図書館（NLM）

The Complex Interplay of Medications in Coronary Artery Disease

This study explores the complex interactions between different medications commonly used to treat coronary artery disease, particularly focusing on the impact of proton-pump inhibitors (PPIs) and CYP2C19 genetic variations on clopidogrel efficacy. This research aims to improve our understanding of these drug interactions and ensure optimal treatment outcomes for patients with coronary artery disease.

Drug Interactions and Individualized Treatment

The study demonstrates the significant impact of PPIs and CYP2C19 genetic variations on clopidogrel's effectiveness in preventing cardiovascular events. The findings highlight the importance of individualized treatment approaches, considering specific patient factors and medication interactions to optimize therapeutic outcomes.

Optimizing Cardiovascular Care

This research contributes to a more nuanced understanding of drug interactions in cardiovascular disease, emphasizing the need for careful consideration of medication combinations and individual patient characteristics. This knowledge helps clinicians provide more effective and personalized treatment plans for patients with coronary artery disease.

Dr.Camel's Conclusion

Just as the desert winds can shift the sands, so too can medication interactions alter the course of treatment. This study serves as a reminder that meticulous attention to drug interactions and individualized care are essential for achieving optimal outcomes in managing coronary artery disease.

Date :
  1. Date Completed 2016-05-16
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26071277

DOI: Digital Object Identifier

10.1007/s00228-015-1882-3

Related Literature

Article Analysis
・Effects of pantoprazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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