Paper Details

  1. Home
  2. Paper Details

Modified Release Biodegradable Polymeric Microspheres of Stavudine: Cell Viability, Cellular Uptake, Hemolysis Studies and In Vivo Pharmacokinetics.

Author: AroraS K, KumarRajendra, SinhaV R, SrivastavaSaurabh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This abstract explores the development of biodegradable polymeric microspheres encapsulating Stavudine (d4T) for the extended treatment of HIV infection. The study demonstrates that these microspheres exhibit good biocompatibility, extended drug release, and reduced likelihood of drug resistance development. The authors suggest that this approach could improve therapeutic efficacy and patient compliance, offering new hope for long-term HIV management.
Paper Details　
Original Abstract of the Article :
Family of retroviruses which replicates through the use of the reverse transcriptase enzyme or the enzyme needed to convert RNA to DNA for replication bears Human Immunodeficiency Virus (HIV). It causes irreversible destruction of the immune system leading to the occurrence of opportunistic infectio...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.2174/1570162x13666150624112345

データ提供：米国国立医学図書館（NLM）

Modified Release Biodegradable Polymeric Microspheres of Stavudine

Human Immunodeficiency Virus (HIV) is a relentless foe, causing irreversible damage to the immune system. This study explores the development and evaluation of biodegradable polymeric microspheres loaded with stavudine (d4T), an antiviral drug used to treat HIV. The researchers sought to create a formulation that would provide sustained drug release, improving efficacy and patient compliance. They conducted cell viability, cellular uptake, hemolysis, and in vivo pharmacokinetic studies to evaluate the safety and efficacy of the microsphere formulation.

Sustained Drug Release and Improved Efficacy

The study demonstrated that the polymeric microspheres exhibited excellent cell viability, biocompatibility, and low hemolytic toxicity. In vivo pharmacokinetic studies revealed sustained drug release from the microspheres for up to a month, resulting in a significantly higher total area under the curve (AUC) for d4T compared to the free drug. These findings suggest that the microsphere formulation could lead to improved therapeutic efficacy and reduced probabilities of developing resistance.

A Promising Approach for HIV Treatment

The development of biodegradable polymeric microspheres offers a promising approach to improving HIV treatment. The sustained release of d4T from these microspheres could lead to more consistent drug levels in the blood, improving efficacy and potentially reducing the need for frequent dosing. Further clinical trials are needed to evaluate the effectiveness of this formulation in HIV-infected patients.

Dr.Camel's Conclusion

Imagine a camel carrying a precious cargo of water through the desert. These microspheres act like the camel's humps, providing a sustained supply of d4T to combat HIV. This innovative approach offers hope for individuals seeking a more convenient and effective way to manage their HIV infection.

Date :
  1. Date Completed 2016-05-16
  2. Date Revised 2019-11-13
Further Info :

Pubmed ID

26103967

DOI: Digital Object Identifier

10.2174/1570162x13666150624112345

Related Literature

Article Analysis
・Effects of d4t
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.