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Safety and tolerability of antipsychotic-mood stabilizer co-treatment in the management of acute bipolar disorder: results from a systematic review and exploratory meta-analysis.

Author: CorrellChristoph U, GallingBritta, GarciaMaryam A, HagiKatsuhiko, OsuchukwuUzoma

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review evaluated the adverse effects of mood stabilizer (MS) plus antipsychotic (AP) co-treatment in patients with acute bipolar disorder (BD). The study found that MS+AP co-treatment was associated with a significantly higher burden of adverse effects, particularly weight gain, extrapyramidal symptoms, and glucose/lipid-related adverse effects.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Mood stabilizer (MS) plus antipsychotic (AP) co-treatment is common in patients with acute bipolar disorder (BD), but adverse effects (AEs) of this strategy have not been systematically reviewed. AREAS COVERED: We conducted a systematic review searching PubMed/MEDLINE and PsycINFO on ...See full text at original site
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引用元：
https://doi.org/10.1517/14740338.2015.1053457

データ提供：米国国立医学図書館（NLM）

Navigating the Risks and Benefits of Antipsychotic-Mood Stabilizer Co-Treatment in Bipolar Disorder

Bipolar disorder, a complex mental health condition characterized by extreme mood swings, presents unique challenges in treatment and management. This study dives into the world of bipolar disorder treatment, examining the potential risks and benefits of combining antipsychotics and mood stabilizers. Researchers meticulously analyzed data from multiple clinical trials, comparing the effectiveness and side effect profiles of these combined treatments.

Weighing the Risks and Benefits of Combined Treatment for Bipolar Disorder

This study provides a comprehensive review of the evidence regarding antipsychotic-mood stabilizer co-treatment in bipolar disorder. The researchers highlight the potential benefits of this combination, but they also emphasize the importance of carefully considering the associated risks, particularly regarding weight gain, extrapyramidal symptoms, and metabolic changes. The study underscores the need for individualized treatment plans, tailored to each patient's specific needs and risk factors.

A Personalized Approach to Bipolar Disorder Management

Bipolar disorder management requires a collaborative approach involving psychiatrists, therapists, and patients. The findings of this study highlight the importance of careful monitoring, individualized treatment plans, and open communication between patients and healthcare providers. If you or a loved one are facing a bipolar disorder diagnosis, consult with a qualified mental health professional for personalized advice and support.

Dr.Camel's Conclusion

Imagine bipolar disorder as a desert mirage, fluctuating between moments of clarity and moments of distorted perception. Just as a camel needs to navigate a complex desert environment, individuals with bipolar disorder require a multifaceted approach to managing their condition. This study offers a detailed examination of the risks and benefits of combining antipsychotics and mood stabilizers, emphasizing the need for careful consideration and individualized treatment plans to effectively manage the challenges of bipolar disorder.

Date :
  1. Date Completed 2016-03-21
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

26107820

DOI: Digital Object Identifier

10.1517/14740338.2015.1053457

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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