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Pharmacodynamic Effects of Ticagrelor Dosing Regimens in Patients on Maintenance Ticagrelor Therapy: Results From a Prospective, Randomized, Double-Blind Investigation.

Author: AngiolilloDominick J, BassTheodore A, BhattiMona, ChoJung Rae, DeGroatChristopher, DunnElizabeth C, FerranteElisabetta, FranchiFrancesco, GuzmanLuis A, Muniz-LozanoAna, RolliniFabiana, SuryadevaraSiva, ZenniMartin M

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the impact of ticagrelor dosing regimens on pharmacodynamic (PD) profiles in patients on maintenance ticagrelor therapy. The study found that a 180-mg loading dose regimen of ticagrelor was associated with more potent and prompt platelet inhibition compared with a 90-mg maintenance dose.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The aim of this study was to assess the impact of ticagrelor dosing regimens on pharmacodynamic (PD) profiles in patients on maintenance ticagrelor therapy. BACKGROUND: Many patients on maintenance P2Y12-inhibiting therapies may require coronary revascularization procedures, raising a c...See full text at original site
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引用元：
https://doi.org/10.1016/j.jcin.2015.02.022

データ提供：米国国立医学図書館（NLM）

The Shifting Sands of Ticagrelor Dosing

In the vast desert of cardiovascular medicine, navigating the intricacies of antiplatelet therapy is crucial for preventing heart attacks and strokes. This research focuses on ticagrelor, a widely used antiplatelet medication, exploring the impact of different dosing regimens on its pharmacodynamic effects. The researchers embark on a scientific expedition to determine the optimal dosage strategy for ticagrelor, aiming to find the best balance between effectiveness and safety.

Ticagrelor: A Double-Edged Sword

This study reveals that ticagrelor, like a double-edged sword, can be wielded effectively with careful consideration. The researchers found that a 180-mg loading dose of ticagrelor was associated with more potent and prompt platelet inhibition compared to a 90-mg maintenance dose. However, the study highlights the importance of individualized dosing strategies, emphasizing the need for careful monitoring and adjustments based on the patient's specific needs and risk factors.

Navigating the Desert of Antiplatelet Therapy

This research provides valuable insights into the complex landscape of antiplatelet therapy. It's like finding a hidden oasis in the desert of treatment options, highlighting the importance of personalized approaches and the need for careful consideration of dosage strategies. The findings underscore the importance of continued research to optimize antiplatelet therapy, ensuring that patients receive the most effective and well-tolerated treatments possible.

Dr. Camel's Conclusion

This research offers a valuable guide to navigating the intricate world of ticagrelor dosing. It's like a compass guiding us through the shifting sands of treatment strategies, highlighting the importance of personalized approaches and careful monitoring. The study reminds us that even in the challenging landscape of cardiovascular medicine, knowledge and careful attention to detail can lead us to better patient outcomes.

Date :
  1. Date Completed 2016-05-24
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

26117466

DOI: Digital Object Identifier

10.1016/j.jcin.2015.02.022

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・Effects of ticagrelor
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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