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A Randomized, Double-Blind, Parallel Study to Evaluate the Dose-Response of Three Different Vitamin D Treatment Schemes on the 25-Hydroxyvitamin D Serum Concentration in Patients with Vitamin D Deficiency.

Author: CavalierEtienne, Da SilvaStéphanie, De NietSophie, JandrainBernard, ScheenAndré, SchleckMarie-Louise, SouberbielleJean-Claude, VanderbistFrancis

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Many people worldwide have low vitamin D levels. This study investigated the effectiveness of different doses of vitamin D in raising vitamin D levels in adults. The study found that higher doses of vitamin D led to faster and greater increases in vitamin D levels, with no significant side effects. The study recommends a single large dose (200,000 IU) followed by a monthly dose of 100,000 IU as the best way to quickly and safely increase vitamin D levels.
Paper Details　
Original Abstract of the Article :
Many people worldwide are vitamin D (VTD) deficient or insufficient, and there is still no consensus on the dose of VTD that should be administered to achieve a 25(OH)D concentration of 20 or 30 ng/mL. In this study, we aimed to determine an adapted supplementation of VTD able to quickly and safely ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517004/

データ提供：米国国立医学図書館（NLM）

Vitamin D Supplementation: Finding the Right Dose for Optimal Health

The desert of [vitamin D deficiency] can be a challenging terrain, impacting the health of many individuals. This study investigates the optimal dose of vitamin D supplementation to achieve sufficient serum levels of 25-hydroxyvitamin D (25(OH)D). The authors randomly assigned 150 healthy adults with low 25(OH)D to three groups, each receiving a different loading dose of vitamin D3 followed by monthly maintenance doses.

Optimal Dose for Vitamin D Supplementation: A Linear Response

The research demonstrated a linear dose-response relationship, showing that higher doses of vitamin D3 resulted in greater increases in 25(OH)D levels. The study concluded that a loading dose of 200,000 IU vitamin D3 followed by a monthly dose of 100,000 IU was the most effective and safe regimen for rapidly correcting vitamin D deficiency. This study provides valuable insights into finding the right dose to achieve optimal vitamin D levels.

Living in the Desert of Vitamin D: Finding the Right Dose

This study highlights the importance of personalized vitamin D supplementation, based on individual needs and serum levels. It's crucial to consult with a healthcare professional to determine the appropriate dose for your specific situation. As a camel, I know that the desert can be harsh, but with the right resources, we can thrive. Remember, seeking advice and finding the right dose is vital for optimizing our vitamin D levels and overall health.

Dr. Camel's Conclusion

This research provides valuable insights into the optimal dose of vitamin D supplementation for achieving sufficient 25(OH)D levels. The study's findings are crucial for healthcare professionals in formulating personalized treatment plans and ensuring the safety and efficacy of vitamin D supplementation.

Date :
  1. Date Completed 2016-03-25
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26151178

DOI: Digital Object Identifier

PMC4517004

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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