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Expression of five acetylcholine receptor subunit genes in Brugia malayi adult worms.

Author: LiBen-Wen, RushAmy C, WeilGary J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the expression of five acetylcholine receptor (AChR) genes in the filarial parasite Brugia malayi. The findings suggest that AChRs may play a role in nervous system development of embryogenesis and spermatogenesis, potentially explaining the broad effects of drugs targeting these receptors in filarial worms.
Paper Details　
Original Abstract of the Article :
Acetylcholine receptors (AChRs) are required for body movement in parasitic nematodes and are targets of "classical" anthelmintic drugs such as levamisole and pyrantel and of newer drugs such as tribendimidine and derquantel. While neurotransmission explains the effects of these drugs on nematode mo...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506985/

データ提供：米国国立医学図書館（NLM）

Expression of Acetylcholine Receptor Subunit Genes in Brugia malayi Adult Worms

This research explores the molecular mechanisms underlying the action of anthelmintic drugs targeting acetylcholine receptors (AChRs) in the parasitic nematode Brugia malayi. The study utilizes a [research methodology] approach to examine the expression of five AChR subunit genes in adult B. malayi worms. The authors have identified the [key findings], revealing the expression patterns of these genes in different tissues and developmental stages of the parasite.

Understanding the Molecular Mechanisms of Anthelmintic Drug Action

This study provides valuable insights into the molecular mechanisms underlying the action of anthelmintic drugs targeting AChRs in parasitic nematodes. The [key findings] highlight the complex expression patterns of AChR subunit genes in B. malayi, offering a deeper understanding of how these receptors function and how anthelmintic drugs interact with them. This research is essential for the development of new and more effective anthelmintic drugs to combat parasitic infections.

The Importance of Research in Parasitic Diseases

This study underscores the importance of ongoing research into parasitic diseases, aiming to develop more effective and targeted treatment strategies. The findings provide valuable insights into the molecular mechanisms underlying the action of anthelmintic drugs, paving the way for new drug discovery and development. This research highlights the need for a multidisciplinary approach, combining molecular biology, pharmacology, and parasitology, to combat the global challenge of parasitic infections.

Dr.Camel's Conclusion

This research delves into the intricate world of parasitic nematodes, exploring the molecular mechanisms underlying the action of anthelmintic drugs. The study provides valuable insights into the complex expression patterns of AChR subunit genes in B. malayi, offering a deeper understanding of how these receptors function and how anthelmintic drugs interact with them. This research is a testament to the ongoing pursuit of knowledge in the field of parasitology, aiming to develop more effective treatments for parasitic infections and improve global health.
Date :
  1. Date Completed 2016-05-19
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

26199859

DOI: Digital Object Identifier

PMC4506985

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in preparation
Languages

English

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